Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Venue 2005
Press Room
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461

Ion Channel Simulations by the TR-PNP Model and the Excess Chemical Potential Approach

S. Hu and K. Hess
Beckman Institute, University of Illinois at Urbana-Champaign, US

ion channel, Poisson-Nernst-Planck, PNP, excess chemical potential, ECP

We describe a new method referred to as TR-PNP model to study general types of nanostructure ion channels. Our method extends the common continuum methods to include particle like properties, such as the ion trapping and release effects. Methods of estimating the characteristic parameters used in the TR-PNP model are discussed. The rate theory is used to estimate the ion release coefficient. We implement a simple toy channel model with a single binding site in terms of both the TR-PNP model and the previous ECP method respectively, and show the equivalence of both approaches under steady state. One of the conditions required for their equivalence is quantitatively determined by an equation relating the TR-PNP parameters to the value of the ECP. Furthermore, we perform a time-dependent study including one to several binding sites inside the pore by using TR-PNP. The transient simulation results quantitatively illustrate the hopping process of ions from one site to the other producing huge currents over short distances within short periods of time. This method can also handle a time scale of microseconds. It is therefore a good candidate to be integrated into a multi-scale simulation framework to provide a bridge between continuum and particle methods.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact