Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Venue 2005
Press Room
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461

A Multi-scale, Integrative Model of Cellular Electrophysiological Response Incorporating Intra/Extra-cellular Transport & Dynamics

J.J. Feng, S. Krishnamoorthy and S. Sundaram
CFD Research Corporation, US

multiscale model, ion channel, deconvolution of AP, simulation

Spurred by the growing confluence of nano and bio technologies, several novel micro/nano platforms (see for example, whole cell patch clamp devices [1]) are emerging for the high-throughput and/or high-fidelity study of the electrophysiological response of a single cell (or a few cells) to external excitation (potential, ion-induced depolarization or hormonal changes etc.). However, a significant challenge in interpreting the data from the instruments is the de-convolution of transport-related effects from pure electrophysiological phenomena, such as the gated responses. In response to this challenge, we have developed a novel multi-scale approach (Figure 1) in which, high-fidelity spatio-temporal models describing intra and extra cellular fluid motion and ion transport (e.g. representing calcium store dynamics) are coupled with an equivalent electric circuit network model describing ion-channel activation. In addition to a clear separation of the transport from the electrophysiology, and thereby more rigorous data analysis, the proposed model will also enable the knowledge-based design and development of novel patch-clamp experimental platforms.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact