Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Venue 2005
Press Room
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461

Multi-scale Drug Release Modeling for Targeted Oral Drug Delivery (TODD)

B.N. Haddish, C. Nyquist, K. Haghighi, H-A Wu, C. Corvalan, J. Rickus and A. Keshavarzian
Purdue University, US

drug delivery, targeted, drug release, mathematical modeling, multi-scale, numerical methods, stochastic modeling

Conventional oral dosage forms deliver their active ingredient at rates that are high initially and decline afterward, showing a first order kinetics with the release determining step considered as the dissolution rate of the active ingredient. However, dosage forms are now being replaced by smart delivery systems (e.g. TODD) that exhibit complex non-linear drug release kinetics. This study deals with the development of a multi-scale mathematical model of the drug release of different commercially available delayed release capsules that deliver 5-ASA (5-Aminosalicylic Acid) to the colon, based on underlying physical and biochemical principles governing the involved processes (e.g., diffusion, dissolution). It was attempted to derive macro-scale transport properties of the capsule components and their interaction with the drug molecule from their molecular descriptors. Coarse grain molecular simulation work is in progress to estimate the transport properties that serve as coupling coefficients between the micro and macro-scales. The existing inter/intra subject variability of the gastrointestinal tract (GIT) environmental factors (e.g. pH and residence time) is also taken into account. The model was validated using in-vitro dissolution experimental data performed by mimicking different pH conditions. Some initial simulation results look promising and the experimental work to obtain the data is underway.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact