Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Venue 2005
Press Room
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461

Bioelectronic Nanoscale Ion Channel Array Stabilization and Active Readout based on Quantum Resonance Interferometry

S. Gulati
ViaLogy Corp., US

bioelectronic nanoscale ion channel array stabilization, active readout, quantum resonance interferometry

We will present an overall systems approach to fabrication of ion-channel array which includes silicon processing, utilization of an AFM based dip-pen nanolithographic (DPN) approach for depositing the individual lipid bilayers and ion channels, a novel polymerization technique to create stable bilayers, selection of biochemical assays for inline detection of ion-channel degradation and partial reconstitution and a novel ultra-weak signal processing technique for detecting ion-transport even with significant channel functional degradation and variation in diffusion efficacy and ion flux rates. Specifically, this presentation will focus on the computational readout backplane based on implementation of quantum resonance interferometry (QRI) for ultra-weak signal detection and amplification technology. QRI is inspired by class of algorithms based on stochastic resonance, where it has been shown that the exploitation of classical noise injection to a dynamical system can increase signal-to-noise ratio (SNR) (Benzi ¡¯81). QRI uses complex noise (derived from simulations of systems with underlying quantum mechanical noise) injection to exploit quantum stochastic resonance (QSR) phenomenology to achieve SNR. This active signal processing technique has been extensively validated on high density microarrays, spotted arrays, protein expression systems, and fluorescence imaging assays. The scientific principals underlying the platform technology – quantum resonance Interferometry (QRI), are analogous to optical interferometry, quantum interferometry and active radar imaging, which enable dramatic improvements in ultra-weak signal imaging. Interferometry techniques have been previously used to measure very small differences in lengths, distances and changes in dimension density and other properties by the interference of two waves of light for optical imaging and communication applications. QRI is exploiting interference between a mathematically transformed, ion-flux signal output from an open ion-channel and an external synthetic stimulus. In a biomarker detection application, the ion channel characteristics are used to construct the external synthetic stimulus. A resonance pattern is generated by iteratively convolving the output flux with the external stimulus.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact