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Effect of Microtopography and Cell Concentration on T Lymphoid Cell Migration during in vitro Extravasation Process

A. Prina-Mello, Y. Volkov and P.J. Prendergast
Trinity College, IE

T cell, cell migration, inflammatory process, extravasation process, implants

The locomotion of leukocyte cells has been proved to be influenced by microtopographical patterns with and without surface chemistry [Prina-Mello et al., 2003, Lo et al., 2000]. In this study, parallel grooves were microfabricated on borosilicate glass surface by wet etching process to create transparent substrates for time lapse microscopy analysis. The locomotory behaviour of lymphoid cells was observed on the microfabricated substrates and compared with plasma treated flat substrates to investigate the incidence of microtopography on cell adhesion and locomotion response. For this purpose the geometrical features of the parallel microchannels (i.e., width, height and depth) were kept constant. Thus, the objective of this work was to demonstrate that the migratory response of malignant T lymphoid cells (HUT78) was enhanced, compared to healthy T lymphoid cells (PBTL) by the topographical patterns of the substrate. Therefore, in this work it was found that the surface topography can influence the motile response of the two different T cell types in different ways, and this can be quantified in terms of motility parameters. This difference may have exploitable applications for the investigation of the inflammatory response of migrating cells on artificially engineered substrates (i.e., dental or bone implant replacement).

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