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Fluorescent Silica Beads for Detection of Cervical Cancer

S. Iyer, Ya. Kievesky, C.D. Woodworth and I. Sokolov
Clarkson University, US

cancer detection, fluorescent bids, glass bids, flow cytometry, cell assays, detection

We present the use of self-assembled fluorescent silica (glass) bids for detection of cervical cancer. The cells from three different individuals (3 normal and 3 tumor) were tested for affinity by using the bids, a few microns glass nanoporous particles which contain florescent dyes sealed inside the pores. We have developed two different methods for detecting the affinity in a Petri-dish. After simple precipitation of the bids onto the cells, the unbounded bids removed by washing. The next method involved using centrifugation for the removal of the unbounded bids. Both methods show unambiguous identification between the normal and tumor cells. To explain the observed phenomena, we studied forces acting between glass 5-micron bids and the cells in-vitro by using direct force measurements with atomic force microscopy. The glass 5-micron sphere was glued to the AFM cantilever, and the forces were collected for 15 normal and 15 tumor vial cells (~100 force curves per cell) in-vitro. The observed forces are in good agreement with the results of the developed affinity methods.

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