Nano Science and Technology InstituteNano Science and Technology Institute
Nano Science and Technology Institute 2005 NSTI Nanotechnology Conference & Trade Show
Nanotech 2005
Bio Nano 2005
Business & Investment
Nano Impact Workshop
Index of Authors
Index of Keywords
Keynote Presentations
Confirmed Speakers
Participating Companies
Industry Focus Sessions
Nanotech Expo
Special Symposia
Venue 2005
Press Room
Site Map
Nanotech 2005 At A Glance
Nanotech Proceedings
Nanotechnology Proceedings
Global Partner
nano tech
Supporting Organizations
Nanotech 2005 Supporting Organization
Media Sponsors
Nanotech 2005 Medias Sponsors
Event Contact
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 353-5004
Fx: (925) 886-8461

Lab-on-a-Chip by Digital Microfluidics

C.-J. Kim

lab on a chip, microfluidics, MEMS, microTAS

Digital Microfluidics is a method of processing liquids in droplet forms. Realizing that typical biochemical laboratory equipments and procedures, either technician-run or robot-run, are operated with discrete amounts of liquids through bottles, pipettes, well plates, etc., we consider aliquot treatment of liquid a more natural fit to build a lab-on-a-chip. While there are several candidate actuation mechanisms to handle liquid droplets, we have converged to electrowetting-on-dielectric (EWOD) in recent years for its efficient driving mechanism, simple fabrication, and low power consumption. Easily automated, digital microfluidics can be used as a discrete, randomly accessed, multi-analyte analyzer, in which reagents or samples, compartmentalized into droplets, can be processed in any desired order in parallel fashion. The principle behind digital microfluidics can be shown by introducing various ways of transporting liquid droplet through modulation of surface tension and demonstrating how to implement them for function. We first show droplets can be created from a reservoir (i.e., digitized), driven (i.e., pumped), divided, and merged using EWOD actuation, either in air or immersed in oil. Following these four basic droplet manipulation functions, we further show that the driving voltage can be lowered (as low as 15 V), multiple droplets can be simultaneously manipulated on an MxN grid, and even the difficult issue of microfluidic mixing can be solved. To demonstrate the simplicity of EWOD microfluidics for system development, we report a stand-alone portable microfluidic system complete with a battery pack. A few more advanced technologies will be unveiled, including electronic tracking of droplets, in-droplet particle separation, sample dilution and concentration, and handling of various biofluids, thus expanding the functionality of digital microfluidics for biomedical applications. Finally, we report on-chip sample processing for MALDI-Mass Spectroscopy as one example of how digital microfluidics are used for specific applications.

Back to Program

Sessions Sunday Monday Tuesday Wednesday Thursday Authors

Nanotech 2005 Conference Program Abstract

Gold Sponsors
Nanotech Gold Sponsors
Silver Sponsors
Nanotech Silver Sponsors
Gold Key Sponsors
Nanotech Gold Key Sponsors
Nanotech Ventures Sponsors
Nanotech Ventures Sponsors
Nanotech Sponsors
News Headlines
NSTI Online Community

© Nano Science and Technology Institute, all rights reserved.
Terms of use | Privacy policy | Contact