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BioNano 2004

Bio Nano 2004

2004 NSTI Bio Nano Conference and Trade Show
March 7-11, 2004
Boston Sheraton Hotel & Copley Convention Center
Boston, Massachusetts, U.S.A.

Recent advances in bio, nano, materials and information technology are combining to enable devices and system with potential global effects on individual and public health and safety, economic, social and political systems, and business and commerce.

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Program Highlights

Keynotes Monday Tuesday Wednesday Thursday

Keynote Lectures

Kurt Krause Nanotechnology and Drug Design
Kurt Krause, University of Houston,
(speaker biography)
Tejal Desai Nanotherapeutics - the Future of Medicine
Tejal Desai, Director, Lab. of Therapeutic Microtechnology, Boston University, (speaker biography)

Monday March 8

1:30 Nanotechnology in Health SciencesBack Bay Ballroom C
 Session chair: Jonathan Rosen, CIMIT & Jeff Borenstein, Draper Labs
1:30 Nanotechnology in Health Sciences (invited)
J. Schloss, NIH, US
2:00 Nanomedicine Applications to Protect Civilians and the Military from Bioterrorism (invited)
J. Baker, University of Michigan, US
2:30 Nanoparticles in Cell Imaging (invited)
J. Frangioni, Beth Israel Deaconess Medical Center, US
3:00 Tiny Technologies in Biomedical Sciences (invited)
M. Toner, Massachusetts General Hospital, Harvard Medical School, US
4:30 Tutorial: Using Nanotechnology to Design Better Soft and Hard Tissue ImplantsFairfax
 Session chair: Tom Webster, Purdue University

Tuesday March 9

10:00 Bio Nano ArraysBack Bay Ballroom C
 Session chair: Srinivas Iyer, LANL
10:00 Overview of Overlapping Bio and Nano Technologies (invited overview presentation)
S. Iyer, LANL, US
10:30 PuraMatrix Nanofiber Hydrogels for Improving Cell-Based Assays and Drug Screening
L. Spirio, PuraMatrix, US
10:50 Detection of DNA Hybridyzation with Impedance Amplifying Labels
K-S Ma, H. Zhou, A. Fischetti, J. Zoval and M. Madou, University of California, Irvine, US
11:10 Functional Nanoarrays for Protein Biomarker Profiling
M. Lynch, C. Mosher, J. Huff, S. Nettikadan, J. Xu and E. Henderson, BioForce Nanosciences, Inc., US
11:30 An Chip-based-Instant Protein Micro Array Formation and Detection System
F-G Tseng, C.E. Ho, M.H. Chen, K.Y. Hung, C.J. Su, Y.F. Chen, H.M. Huang and C-C Chieng, National Tsing Hua University, TW
11:50 High-Resolution Electrochemical In Situ Printing
R.D. Egeland and E.M. Southern, Oxamer & Oxford Gene Technology, UK
1:30 Bio Nano AnalysisBack Bay Ballroom C
 Session chair: Bart Romanowicz, NSTI
1:30 MALDI- or ESI? Pros and Cons for Protein and Small Molecules (invited)
J. Olivares, A. Dattelbaum, A. Shreve and S. Iyer, Los Alamos National Lab, US
2:00 Biochips for Genetic Sample Preparation: From Micro- to Nano- Analytical Environments (invited)
P. Grodzinski, Los Alamos National Lab, US
2:30 Microfabricated Fluorescence-Activated Cell Sorter with Hydrodynamic Flow Manipulation
H. Bang, C. Chung, J.K. Kim, S. Kim, S. Chung, D-C Han and J.K. Chang, School of Mechanical & Aerospace Eng., Seoul National University, KR
2:50 Development of a Slug-Flow PCR Chip with Minimum Heating Cycle Times
S. Hardt, D. Dadic, F. Doffing, K.S. Drese, G. Münchow and O. Sörensen, Institute of Microtechnology Mainz, DE
3:10 Composable System Simulation of Dispersion in Complex Electrophoretic Separation Microchips
Y. Wang, Q. Lin and T. Mukherjee, Carnegie Mellon University, US
3:30 Visualizing Individual Rhodopsin (a G Protein-Coupled Receptor) Molecules in Native Disk and Reconstituted Membranes via Atomic Force Microscopy
E.J. Choi, A.J. Jin, S-L Niu, P.D. Smith and B.J. Litman, National Institutes of Health, US
3:50 Design and Analysis of Micro/Nano Electrokinetic Systems
S. Krishnamoorthy, J.J. Feng and S. Sundaram, CFD Research Corporation, US
4:30 Membrane and Cell Mimetic SystemsBack Bay Ballroom C
 Session chair: Atul Parikh, UC-Davis
4:30 Membrane Photolithography and Applications in Modeling Cell Surface Dynamics (invited)
A. Parikh, University of California Davis, US
4:50 Hybrid Supported Membrane - live cell synapses (invited)
J. Groves, Lawrence Berkeley Labs, US
5:10 Artificial Synapse Arrays: Using Synthetic Surfaces to Deconstruct T Cell Activation (invited)
D. Irvine, Massachusetts Institute of Technology, US
5:30 Microdevices for Real-time Biomolecular Detection (invited)
S. Manalis, MIT Media Laboratory, US
5:50 Inner View of Molecular Assembly within the Inflammatory Synapse (invited)
S. Simon, University of California Davis, US
6:00 Poster Session A (6:00 - 7:30)Constitution Ballroom
Bio Nano AnalysisConstitution Ballroom
- Sample-Shunting Based PCR Microfluidic Device
P-A Auroux, P.J.R. Day and A. Manz, Imperial College, UK
- Highly Efficient Electro-permeabilization of Mammalian Cells Using Micro-electroporation Chip
Y.S. Shin, J.K. Kim, S.H. Lim, Y.K. Lee, K. Cho, Y. Lee, S. Chung, C. Chung, D-C Han and J.K. Chang, Seoul National University, KR
- Effect of Substratum Morphology on Cell Behavior
W-T Su, I-M Chu, J-Y Yang and C-D Lin, National Nano Device Laboratories, TW
- An Injector Component Model for Complete Microfluidic Electrokinetic Separation Systems
R. Magargle, J.F. Hoburg and T. Mukherjee, Carnegie Mellon University, US
Bio Nano Computational Methods and ApplicationsConstitution Ballroom
- Numerical Modeling of Diffusion in Extracellular Space of Biological Cell Clusters and Tumors
J. Berthier, F. Rivera and P. Caillat, CEA-LETI, FR
- Mathematical Modeling for Immunocolloid Labeling
C. Raymond and P. Milewksi, New Jersey Institute of Technology, US
- Crystallization of Membrane Protein Nanoparticles
A. Shiryayev, E.F. Holby and J.D. Gunton, Lehigh University, US
- Monte Carlo Study of Models of Membrane Proteins
T.P. Connor, D.L. Pagan, A. Shiryayev and J.D. Gunton, Lehigh University, US
Micro Fluidics and Nanoscale TransportConstitution Ballroom
- Nano-structure and Phase Transitions in the Liquid Phase of Metallic and Non-metallic Elements
G.C. Vezzoli, Institute for the Basic Sciences, US
- Application of Local Radial Basis Function-based Differential Quadrature Method in Micro Flows
D. Xu, H. Ding and C. Shu, Agency for Science Technology and Research, SG
- Numerical Visualization and Quantification of Chaotic Mixing for Micromixers
T.G. Kang and T.H. Kwon, Pohang University of Science and Technology, KR
- Galilean Invariant Viscosity Term for an Athermal Integer Lattice Boltzmann Automaton in three Dimensions
M.C. Geier, A. Greiner and J.G. Korvink, IMTEK, Albert Ludwigs University Freiburg im Breisgau, DE
- Liquid Disintegration: Investigation of Physics by Simulation
J. Zeng and T. Korsmeyer, Coventor, Inc., US
- Capillary Passive Valve in Microfluidic System
H. Cho, H-Y Kim, J.Y. Kang and T.S. Kim, Microsystem Research Center, Korea Institute of Science and Technology, KR
- Clogging Pressures of Bubbles in Microchannel Contractions: Theory and Experiments
M.J. Jensen, X. Wang, D. Attinger and H. Bruus, Mikroelektronik Centret, DTU, DK
- In-Plane Micropump: Design Optimization
J. Sin, W.H. Lee and H.E. Stephanou, RPI, US
- Analysis of Blood Extraction from a Lancet Puncture
R.J. Kuriger and B.F. Romanowicz, CFD Research Corporation, US

Wednesday March 10

10:00 Bio Nano Computational DesignBack Bay Ballroom C
 Session chair: Xavier Avula, Washington University in St. Louis
10:00 Biomolecule Electrostatic Optimization with an Implicit Hessian
J.P. Bardhan, J.H. Lee, M.D. Altman, S. Leyffer, S. Benson, B. Tidor and J.K. White, Massachusetts Institute of Technology, US
10:20 Development of an Advanced Simulation System for the Analysis of Particle Dynamics in LASER based Protein Ion Sources
A. Hieke, Ciphergen Biosystems, Inc., US
10:40 A Monte Carlo Study of a Model of Globular Protein Nanoparticles
D.L. Pagan, M.E. Gracheva and J.D. Gunton, Lehigh University, US
11:00 DNA and Estrogen Receptor Interaction Revealed by the Fragment Molecular Orbital Method -Implementation of SCF Convergence-
T. Watanabe, Y. Inadomi, S. Tanaka and U. Nagashima, National Institute of Advanced Industrial and Science and Technology, JP
11:20 Resolved Particle Simulations of Microsphere/Cell-based Bioanalytic Systems
K. Pant, B.F. Romanowicz and S. Sundaram, CFD Research Corporation, US
11:40 Self Assembly of Globular Protein Nanoparticles
A. Shiryayev and J.D. Gunton, Lehigh University, US
1:30 Bio Nano Systems and ChemistryBack Bay Ballroom C
 Session chair: Chris Menzel, NSTI
1:30 Forisomes: Mechano-Proteins that Exert Force in Contraction and Expansion
M. Knoblauch, G.A. Noll, D. Prüfer, H. Jaag, M.E. Fontanellaz, I. Schneider-Hüther, A.J.E. van Bel and W.S. Peters, Fraunhofer Institute IME, DE
1:50 Development of a Self-Assembled Muscle-Powered Piezoelectric Microgenerator
J. Xi, E. Dy, M-T Hung and C. Montemagno, UCLA, US
2:10 Nanosecond Pulsed Electric Fields Trigger Intracellular Signals in Human Lymphocytes
P.T. Vernier, Y. Sun, L. Marcu, C.M. Craft and M.A. Gundersen, University of Southern California, US
2:30 Optically Addressable Capsules
B. Radt and F. Caruso, University of Melbourne, AU
4:30 Ion Channels as Nano DevicesBack Bay Ballroom C
 Session chair: Wolfgang Windl, Ohio State
4:30 The Dielectric Boundary Force in Ion Channels: The Case of Gramicidin
B. Nadler, U. Hollerbach and R.S. Eisenberg, Yale University, US
4:50 Brownian Dynamics Simulation of Transport Properties in Potassium Ion Channels
S. Aboud, D. Marreiro, M. Saraniti and R.S. Eisenberg, IIT/Rush University, US
5:10 BioMOCA: A Transport Monte Carlo Approach to Ion Channel Simulation
T.A. van der Straaten, G. Kathawala and U. Ravaioli, Beckman Institute, University of Illinois, US
5:30 Selectivity: How Biological Ion Channels Distinguish Among Different Ion Species
D. Gillespie, W. Nonner and R.S. Eisenberg, Rush University Medical Center, US
5:50 Hybrid MD-PNP Simulations of the Alpha-Hemolysin Open Ion Currents
I. Cozmuta, J.T. O'Keeffe and V. Stolc, Eloret Corp, NASA Ames Research Center, US
6:10 Toward an Integrated Computational Environment for Multiscale Computational Design of Nanoscale Ion Channel Semiconductors
S. Natarajan, S. Varma, Y. Tang, S. Parker, J. Mashl and E. Jakobsson, NCSA, US
6:00 Poster Session B (6:00 - 8:00)Constitution Ballroom
Bio Nano Systems and ChemistryConstitution Ballroom
- Viruses as Optical Probes
E-S Kwak, C. Chen, C. Cheng Kao, W.L. Schaich and B. Dragnea, University of Indiana, US
- pH Dependent Optical Properties of Surface Modified Gold Nanoparticles Using a Bovine Serum Albumin Coating
Y. Xu, K.A. Linares, K. Meehan, B.J. Love and N.G. Love, Virginia Polytechnic Institute and State University, US
- Internalization of Nanoparticles in the Middle Ear Epithelium in Response to an External Magnetic Field: Generating a Force
K. Dormer, C. Seeney, A. Mamedov and F. Mondalek, University of Oklahoma, Coll. of Med., US
- High Throughput in-silico Screening against Flexible Protein Receptors
H. Merlitz and W. Wenzel, Forschungszentrum Karlsruhe, DE
- Actin Adsorbed on HOPG and Mica Substrates: Characterization and Manipulation by Atomic Force Microscopy
D.V. Nicolau, G.S. Watson, C. Cahill, J. Blach and S. Myhra, Swinburne University, AU
Bio Nano AnalysisConstitution Ballroom
- Dielectrophoresis (DEP) of Cells and Microparticle in PDMS Microfluidic Channels
T.T. Kanagasabapathi, C.J. Backhouse and K.V.I.S. Kaler, University of Calgary, CA
- Dry Microarrays: A Generalized Data Source for Genome and Proteome Analysis
G. Sampath, The College of New Jersey, US
- Molecular Simulation of DNA Microarrays - an Application of 2D particle mesh Ewald algorithm -
T. Watanabe, M. Kawata and U. Nagashima, National Institute of Advanced Industrial and Science and Technology, Grid Technology Research Center, JP
- Development and Characterization of a 2-D microchip-based Protein separation system.
J.J. Feng, V Olazábal, J.A. Olivares, S. Sundaram, S. Krishnamoorthy and S. Iyer, Los Alamos National Laboratory, US
- Amplification of Protein Adsorption on Micro/Nanostructures for Microarray Applications
E.P. Ivanova, Y.V. Alekseeva, D.K. Pham, L. Filipponi and D.V. Nicolau, Swinburne University, AU
- Evaluation of Electric Impedance Spectra for Single Bio-Cells with Microfluidic Devices using Combined FEMLAB/HSPICE Simulated Models
V. Senez, T. Yamamoto, B. Poussard, T. Fukuba, J.M. Capron and T. Fujii, LIMMS/CNRS-IIS - University of Tokyo, JP
Bio Micro SystemsConstitution Ballroom
- Modeling of the Dielectrophoretic Forces Acting upon Biological Cells: A Numerical Comparison between Finite Element/Boundary Element Maxwell Stress Tensor Methods and Dipole Point Approach
A. Benselama, P. Pham, É. Canot, CEA, FR
- An Approach for Fabrication of Polymer-based Bio-analytical Microfluidic Devices
M. Wang, K-Y Weng, C-C Huang, W-P Liu and L-Y Yao, Industrial Technology Research Institute, TW
- A Generic Sensor for Ultra Low Analyte Concentration Detection
J. Hedley, C.J. McNeil, J.S. Burdess, A.J. Harris, M.G. Dobson, G. Suarez and H. Berney, Newcastle University, UK
- Characterization of Micropumps for Biomedical Applications
Y. Haik, J. Hendrix, M. Kilani, P. Galambus and C-J Chen, Florida State University, US
- Modeling of Dielectrophoresis for Handling Bioparticles in Microdevices
G.F. Yao, Flow Science Inc., US
- Cell Based Biosensors
C.S. Ozkan, Univeristy of California at Riverside, US
- Quadruptlets-Microneedle Array for Blood Extraction
S. Khumpuang, G. Kawaguchi and S. Sugiyama, Ritsumeikan University, JP
Bio SensorsConstitution Ballroom
- A Disposable Glucose Biosensor Based on Diffusional Mediator Dispersed in Nanoparticulate Membrane on Screen-Printed Carbon Electrode
Z. Gao, F. Xie, M. Shariff, M. Arshad and J.Y. Ying, Institute of Bioengineering and Nanotechnology, SG
- A Microfluidic System with Nonenzymatic Glucose Sensor
S. Joo, S. Park, H. Lim, T.D. Chung and H-C Kim, Seoul National University, KR
- Glucometers to Detect for Heart Attack
Y. Haik, A. Qablan, A. Zwolinski, C-J Chen, Florida State University, US
Micro Fluidics and Nanoscale TransportConstitution Ballroom
- Polymeric Micropump with SU-8 Check Valves Assembled by Lamination Technique
T.Q. Truong and N.T. Nguyen, Nanyang Technological University, SG
- Electrokinetic Instability Mechanism of Double-layered Miscible Fluids with Different Electrolyte Concentrations in DC Electric Field
J.W. Park, K.H. Kang and K.Y. Huh, Pohang University of Science and Technology, KR
- SOI Processing of a Ring Electrokinetic Chaotic Micromixer
Y.T. Zhang, H. Chen, I. Mezic, C.D. Meinhart, L. Petzold and N.C. MacDonald, university of california, santa barbara, US
- Spacific Flow Control Systems Using IR Laser Induced Sol-Gel Transfer of Hydrogel
J. Tanaka, Y. Shirasaki, M. Tatsuoka, T. Funatsu, S. Watabe, S. Shoji, T. Edura, J. Mizuno and Y. Wada, Waseda University, JP
- Optimization of Mixing in an Active Micromixing Device
G. Mathew, I. Mezic, R. Serban and L. Petzold, University of California, Santa Barbara, US
- Droplet Movement Induced by Nano Assembled Molecules And Micro Textures
F-G Tseng and S.C. Chien, National Tsing Hua University, ESS Dept., TW
- Analysis of AC-Driven Electroosmotic Flow in a Microchannel Packed with Microspheres
Y.J. Kang, C. Yang and X.Y. Huang, Nanyang Technological University, SG
- An Effective Passive Micromixer Employing Herringbone Structure
C-F Kung, C-F Chen, C-C Chu and F-G Tseng, IAM, National Taiwan University, TW
- Novel 2D Interfaces for Nanoelectrospray-Mass Spectrometry
S. Arscott, S. Le Gac, C. Druon, P. Tabourier and C. Rolando, USTL, FR
- DEP Particle Dynamics and the Steady Drag Assumption
S.T. Wereley, I. Whitacre, R. Bashir and H.B. Li, Purdue University, US

Thursday March 11

9:40 Bio Molecular MotorsBack Bay Ballroom C
 Session chair: Srinivas Iyer, LANL
9:40 A Molecular Motor that Links the Biological and Silicon Worlds
T. Robinson, A. Blundell, C.F. Dutta and K. Firman, University of Portsmouth, UK
10:00 Viral Protein Linear (VPL) Nano-Actuators
A. Dubey, G. Sharma, C. Mavroidis, S.M. Tomassone, K.P. Nikitczuk and M.L. Yarmush, Northeastern University, US
10:20 Biomimetic Molecules as Building Blocks for Synthetic Muscles - A Proposal
A.H. Flood, J. Badjic, J-Y Han, C. Pentecost, B.H. Northrop, S.J. Cantrill, K.N. Houk and J.F. Stoddart, UCLA and CNSI, US
10:40 MEMS Biofluidic Device Concept Based on a Supramolecular Motor
M.J. Knieser, R. Pidaparti, F. Kadioglu, R.D. Harris, M.R. Knieser and A. Hsu, Indiana Univerisity Purdue University Indianapolis, US
11:00 A Mechanistic Model of the Motility of Actin Filaments on Myosin
D.V. Nicolau_Jr. and D.V. Nicolau, Swinburne University, AU
11:20 RNA Polymerase as an Information-Dependent Molecular Motor
R.T. Pomerantz, M. Anikin, J. Zlatanova and W.T. McAllister, SUNY Downstate Medical Center, US
11:40 A Proposal Conceptualization of a Hybrid Bio-Moto-Reductor Actuator and the ''Virtual Shaft'' Hypothesis
M.A. Venegas, NSTI - Affiliate, MX
1:30 Tutorial: Nano-Bio-Micro FluidicsBack Bay Ballroom B
 Session chair: Steve Wereley, Purdue University
1:30 Bio SensorsBack Bay Ballroom C
 Session chair: Srinivas Iyer, LANL
1:30 Optical Detection of Integrin AvB3 Using a Nanostructured Lipid Bilayer Membrane Biosensor
O. Worsfold and T. Nishiya, Fujirebio Inc., JP
1:50 Micro-Patterning of Ionic Reservoirs within a Double Bilayer Lipid Membrane to Fabricate a 2D Array of Ion-Channel Switch Based Electrochemical Biosensors
J.M. Sansiñena, C.K. Yee, A. Sapuri, B.I. Swanson, A. Redondo and A.N. Parikh, Los Alamos National Laboratory, US
2:10 Potentiometric Biosensors Based on Silicon and Porous Silicon
I. Basu, R.V. Subramanian, A. Mathew, A. Chadha and E. Bhattacharya, Indian Institute of Technology Madras, IN
2:30 Bio-Impedance Sensing Device (BISD) for Detection of Human CD4+ Cells
N.N. Mishra, S. Retterrer, T.J. Zieziulewicz, M. Isaacson, D. Szarowski, D.E. Mousseau, D.A. Lawrence and J.N. Turner, New York City Department of Health, US
2:50 Behavior of Living Human Neural Networks on Microelectrode Array Support
R. Pizzi, F. Gelain, A. Fantasia, D. Rossetti and A. Vescovi, University of Milan, IT
3:10 Glucose Sensors Based on Glucose Oxidase Immobilized in Polypyrrole-Polyacrylamide Microparticles
E. López-Cabarcos, J. Rubio-Retama, D. Mecerreyes and B. López-Ruiz, University Complutense, ES
Keynotes Monday Tuesday Wednesday Thursday


Topics and Application Areas

The major areas of activity in the development of biotechnology and life sciences solicited and expected at this conference include but are not limited to:

  • Bio Arrays and Proteomics
  • Bio Micro Systems
  • Bio Nano Systems and Chemistry
  • Bio-Molecular Analysis and Characterization
  • Biohazard Detection
  • Bioinformatics/Computational Genomics
  • Biomimetic Membranes
  • Biomimetics
  • Biomolecular Motors
  • Carbon Nano Structures
  • Cell Signaling Pathways
  • Computational Drug/Molecular Design
  • Computational Biology
  • Diagnostics
  • Drug Discovery
  • Drug Design
  • Computational Methods and Numerics
  • Functional/Structural Genomics
  • Gengineering
  • Genomics
  • Homeland Defence
  • Lab-on-Chip
  • Mathematical Biology
  • Micro Fluidics
  • Molecular Modeling
  • Nano Fluidics and Transport
  • Nanostructures: Biological Ion Channels to Thin Oxides
  • Physical Chemistry of Nanomaterials
  • Protein Engineering
  • Proteomics
  • Rational Drug Design
  • Self-Replicating/Organizing Systems
  • Structural Biology
  • Surfaces and Films
  • Theranostics
  • Transport Mechanisms

A technical digest on CDROM, consisting of articles submitted by authors of both oral and poster papers will be distributed to participants at registration.

Bio Nano Conference Organization

Topical and Regional Scientific Advisors and Chairs


Srinivas Iyer, Los Alamos National Laboratory, USA


Kurt Krause, University of Houston, USA

Biotechnology Conference Committee

Dirk Bussiere, Chiron Corporation, USA
Amos Bairoch, Swiss Institute of Bioinformatics, Switzerland
Stephen H. Bryant, National Institute of Health, USA
Fred Cohen, University of California, San Francisco, USA
Daniel Davison, Bristol Myers Squibb, USA
Robert S. Eisenberg, Rush Medical Center, Chicago, USA
Andreas Hieke, Ciphergen Biosystems, Inc., USA
Leroy Hood, Institute for Systems Biology, USA
Sorin Istrail, Celera Genomics, USA
Srinivas Iyer, Los Alamos National Laboratory, USA
Brian Korgel, University of Texas-Austin, USA
Kurt Krause, University of Houston, USA
Daniel Lacks, Tulane University, USA
Mike Masquelier, Motorola, Los Alamos NM, USA
Atul Parikh, University of California, Davis, USA
Andrzej Przekwas, CFD Research Corporation, USA
George Robillard, BioMade Corporation, Netherlands
Jonathan Rosen, Center for Integration of Medicine and Innovative Technology, USA
Tom Terwilliger, Los Alamos National Laboratory, USA
Michael S. Waterman, University of Southern California, USA

Technical Program Chairs

Matthew Laudon, NSTI-ACRS, USA
Bart Romanowicz, CFDRC, USA

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