Materials for Drug & Gene Delivery & Cancer Nanotech

How does nanoparticle design affect targeting selectivity: computer modeling

Dormidontova E.E., University of Connecticut, US

One of the areas of active development of modern nanomedicine is application of polymer tethered nanoparticles for drug/gene delivery and imaging. The optimal nanoparticle design for targeting one type of cell may be quite different [...]

TiO2-Nanowired cerebrolysin attenuated hyperthermia induced ubiquitin overexpression and brain pathology

Sharma A., Sharma H.S., Muresanu D.F., Patnaik R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Hyperthermia and heat stress induces brain damage. This is specially applicable to Military personals during combat operations in the Middle East where heat is a big problem 2. Intoxication of nanoparticles exacerbates heat-induced brain [...]

Nano-Power Implantable Autonomous Closed-Loop CMOS Nerve-Growth-Factor Delivery Microsystem for Neurological Disorders Personalized Therapy

Poustinchi M., Musallam S., McGill University, Neural Prosthetics Laboratory, CA

480 million patients around the globe suffer from neurological disorders which are the fastest-growing disease worldwide. Many neurological and psychiatric conditions are the result of abnormal neurotransmitter concentrations in the brain. Our ultimate goal is [...]

Applying Plasmon Resonant Coating to Commercial Liposomal Delivery Systems

Knights-Mitchell S.S., University of Arizona, US

Multiple drug-encapsulated liposomes have been successfully marketed as pharmaceuticals within the past two decades. Some of these liposomal drugs have been shown to selectively localize within tumors. However, one limitation is the inability to control [...]

Shell Thickness Control of Mesoporous Silica Hollow Capsules and Their Release Behavior

Yamaguchi Y., Kato N., Meiji university, JP

we propose the method to control the shell thickness of the mesoporous silica hollow capsules (MSHCs) and the method to load the materilas into the MSHCs. The release behavior was also invesitgated. The template-assisted method [...]

Biodegradable Polymer-Based Composite Particles for Targeted Drug Delivery Carriers with Magnetic Response

Kitamoto Y., Oka C., Ushimaru K., Tsuge T., Horiishi N., Tokyo Institute of Technology, JP

Core–shell composite particles with biodegradability and magnetism were prepared for targeted drug delivery based on magnetic guidance. The composite particles were composed of a core of biodegradable polymer and a shell of assembled magnetic iron [...]

Synthesis and evaluation of T85-LPEI copolymers for pDNA delivery

Wang M.X., Carolinas Medical Center, US

In this study, a series of low molecular weight PEI (LPEI) modified with Tween 85 were prepared by varying feed ratio and PEI size (Mw: 0.8k, 1.2k and 2.0k Da) for gene delivery. The Mws [...]

Fabrication and characterization of core-shell microspheres composed of pectin and arabinoxylans as controlled release systems for insulin

Díaz-Baca J., Martinez-Lopez A.L., Carvajal-Millan E., Pérez-López E., González-Ríos H., Balandrán-Quintana R., Rascón-Chu A., Centro de Investigacion en Alimentacion y Desarrollo A.C., MX

Currently incidence of diabetes is increasing worldwide very, WHO classifies it as an epidemic (WHO, 2012) and in Mexico is the leading cause of death (IMSS, 2012). The traditional form of insulin subcutaneous injection, is [...]

Simulation and synthesis of a self-assembling and tumor-targeted drug delivery system

McTaggart M., Li X., Malardier-Jugroot C., Royal Military College of Canada, CA

Poly(styrene-alt-maleic anhydride) is an amphiphilic alternating copolymer that self-assembles into supramolecular nanotubes in aqueous, physiological-pH environments. Its 2nm hydrophobic inner diameter is stable in neutral pH solution but opens as pH drops. Folate-conjugated nanotubes could [...]

Activation of antigen presenting cells and induction of mucosal antibodies by Chlamydia trachomatis outer membrane peptide encapsulated within PLA-PEG nanoparticles

Dixit S., Taha M., Singh S.R., Dennis V.A., Alabama State University, US

In pursuit of a vaccine against Chlamydia trachomatis, the most reported bacterial sexually transmitted infection, we previously reported that encapsulation of M278, a peptide derived from the major outer protein of C. trachomatis within PLA-PEG [...]

Nano Drug delivery by Single-wall carbon nanotubes (SWCNTs) in the Central nervous system induces neurotoxicity. Potential neuroprotective effects of Cerebrolysin

Sharma A., Sharma H.S., Muresanu D.F., Patnaik R., Tian Z.R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

Single wall carbon nanotubes (SWCNTs) are preferred vehicle for nano drug delivery in cancer therapy. However, the effects of SWCNTs alone in vivo situations are not well explored. Thus, the need of the hour is [...]

β3 Integrin siRNA-Loaded Multifunctional Nanoparticle Therapy for Metastatic Breast Cancer

Gujrati M., Parvani J.G., Schiemann W.P., Lu Z.R., Case Western Reserve University, US

Successful siRNA-mediated cancer therapy requires the use of multifunctional nanoparticle systems to overcome the barriers associated with delivery. We have recently developed a cationic lipid-based carrier, ECO, which efficiently delivers siRNA intracellularly to induce potent [...]

Controlled Intracellular Release of Camptothecin by Glutathione-Driven Mechanism

Botella P., Muniesa C., Vicente V., Fabregat K., Cabrera A., Instituto de Tecnologia Quimica (UPV-CSIC), ES

Direct coupling of camptothecin (CPT) to nanoparticles is circumvented by the reduced therapeutic activity of its structure-modified derivatives. To negotiate this problem, we have developed a novel CPT nanoplatform based in a mercapto-functionalized silica hybrid [...]

Investigating Modified Oligonucleotides as Robust, Programmable Release Agents

Tohver Milam V., Eze N., Georgia Institute of Technology, US

While LNA has been examined as a therapeutic agent in various antisense scenarios, we are exploring LNA as a programmable biomaterials assembly and disassembly tool under isothermal conditions. To drive isothermal disassembly of LNA-linked objects, [...]

In Vitro Delivery of Docetaxel to Cancer Cells by Hybrid PLGA@Organosilica Nanoparticles with Redox-Sensitive Molecular Gates

Botella P., Quesada M., Vicente V., Cabrera A., Fabregat K., Instituto de Tecnologia Quimica (UPV-CSIC), ES

We have developed a novel hybrid material based in spherical PLGA nanoparticles containing hydrophobic molecules which have been covered by a thin layer (6-10 nm) of a redox-responsive amorphous organosilica shell. The outer layer incorporates [...]

Study on the Composite with Sequential and Sustained Release of Multiple Growth Factors for Bone Repair

Liao Y., Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University, TW

In this study, a PLGA/PVA microsphere and a chitosan-based hydrogel loading FITC were prepared to be a composite. The encapsulation of FITC in PLGA/PVA microspheres and the bonding of crosslink in chitosan-based hydrogel were confirmed. [...]

Nanodelivery of Cerebrolysin as adjunct therapy with Functionalized magnetic iron oxide nanoparticles enhances neuroprotection

Sharma A., Sharma H.S., Muresanu D.F., Tian Z.R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Functionalized magnetic iron oxide nanoparticles (FMIONPs) are used as adjunct therapy in cancer to effectively enhance cellular damages of cancerous cells sparing normal cells using chemotherapy or heat treatment. The FMIONPs are considered safe. [...]

Thymoquinone nanoparticle formulation and in vitro efficacy

Fakhoury I.H., Saad W.S., Gali-Muhtasib H.U., Schneider-Stock R., American University of Beirut, LB

The work summarized here pertains to the formulation of thymoquinone into controlled size nanoparticles using a recently developed solvent precipiation technique termed Flash Nanoprecipiation. Using a diblock copolymer of poly(styrene-b-ethylene oxide) as the stabilizing polymer, [...]

Cu/TiO2-SiO2 Nanostructured Materials for Brain Cancer Treatment

Ortiz-Islas E., Guevara P., Gómez E., Monroy H., Novaro O., National Institute of Neurology and Neurosurgery, MX

In the present work, we are reporting the toxic effect to brain cancer cells exerted by copper complexes loaded (CC) on a binary oxide. For this purpose, the TiO2-SiO2 oxide was prepared using the sol-gel [...]

Inductive Nano Targeted Electromagnetic Therapy

Meymanat M., Zanjan University of Medical Sciences, Zanjan, Iran, IR

A Biofunctionalized conductor Nano-Particle which can be made of ferromagnetic and conductor materials, capable to attach specifically biologic targets in vivo and in vitro by using molecules for specific attachment (such as monoclonal antibody) is [...]

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