Authors: H.S. Sharma, L. Feng, J.V. Lafuente, D.F. Muresanu, Z.R. Tian, R. Patnaik, A. Sharma
Affilation: Uppsala University, Sweden
Pages: 246 - 249
Keywords: nanowired mesenchymal stem cells, neuroprotection, brain pathology, heat stress, diabetes
Stem cell transplantation or injection is associated with neuroprotection in stroke and in central nervous system (CNS) injury. However, role of stem cells in hyperthermia induced brain pathology is not investigated so far. Our previous data suggests that whole body hyperthermia (WBH) akin to our soldiers engaged in combat operations in desert environment in summer leads to severe brain pathology. Furthermore, when diabetic animals are exposed to identical WBH at 38°C for 4 h resulted in exacerbation of brain pathology and functional disabilities. In present investigation we administered commercially available mesenchymal stem cells (MSCs) either alone or TiO2 nanowired (1 million cells intravenously 1 week before WBH) in animal following heat stress in healthy or diabetic rats. Our observations showed that TiO2 nanowired MSCs significantly attenuated or ameliorated brain pathology in diabetic rats after WBH, whereas normal MSCs are capable to reduce brain pathology only in healthy animals following hyperthermia. These observations are the first to suggest that nanowired MSCs are more portent in inducing neuroprotection under comorbidity factors, e.g., diabetes in hyperthermia, not reported earlier.