Authors: J. Karlsson
Affilation: Chalmers University of Technology, Sweden
Pages: 250 - 253
Keywords: biomedical implant, mesoporous titania, local drug delivery, tissue integration
There is an ongoing development to improve osseointegration of bone-anchored implants. Despite progress, further improvements are needed in order to allow treatment of patients that suffers from low bone amounts or poor bone quality, and also to permit earlier loading of the implant device. In this work, thin films of mesoporous (MP) titania were used as a local drug delivery system to obtain an enhanced fixation of implants. Initially, two drug candidates were examined, Alendronate (ALN) and Raloxifene (RLX). Significantly enhanced osseointegration was observed for drug containing surfaces compared to control surfaces without drugs. The release kinetics of C-14 labeled ALN was also evaluated in vivo. Autoradiography data demonstrated a sustained release and that the released drug remained in the close vicinity of the implant surface. A crucial aspect is to control the interplay between the implanted device and the host tissue. We have demonstrated that atomic probe tomography (APT) could be utilized to examine the biomaterial/tissue interface. The APT reconstructions showed atomically resolved tissue integration. Moreover, raman was implemented as an ex vivo analytical technique. It showed that the newly formed bone around the drug containing implants was more mature compared to when no drugs was present.