Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 4: Cancer Nanotechnology & Nano Medical Sciences

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Authors:T. Yang, B. Bouchard, A. Cook, J. Hu, J. Hao, S. Bai
Affilation:Husson University, US
Pages:381 - 384
Keywords:PEGylation, long-acting anticoagulant, nanoconjugate
Abstract:Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for frequent injections creates barriers to patient compliance, primarily during long-term management. Conjugation of drugs with polyethylene glycol (PEGylation) has been shown to significantly increase the circulating time of therapeutics. In order to develop a LMWH analogue with the extended circulating half-life, PEGylated LMWHs were prepared and characterized as well as their safty and pharmacokintics profiles were evaluated in a cell or a rodent model, respectively.
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