Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 4: Cancer Nanotechnology & Nano Medical Sciences

The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents

Authors:O. Ogunwuyi, E. Akala
Affilation:Howard University, US
Pages:418 - 419
Keywords:nanoparticles, poly-Ɛ-caprolactone, in-situ polymerization
Abstract:Polyesters have gained a lot of prominence because of their use in drug delivery. They are the most widely used polymers in biomedical applications because they are biocompatible, non-immunogenic, non-toxic and are approved for use in vivo by the Food and Drug Administration (FDA). The polyesters include poly(lactic acid), poly glycolic acid, poly(lactide-co-glycolide), and poly-ε- caprolactone. Over the years, polyesters have been fabricated into nanoparticles using preformed polymers. In recent time, in-situ polymerization technique is being applied to the fabrication of nanoparticles. The technique has a lot advantages such as the opportunity to tether various materials to the nanoparticles and one step synthesis of the nanoparticles. In this study, stealth poly-ε-caprolactone nanoparticles have been fabricated by the in-situ polymerization method. However, prior to the use of the ε-caprolactone as a macromonomer, it was end-functionalized to give it a polymerizable end-group. The nanoparticles particles were analyzed by scanning electron microscopy and particle size determinations.
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