Authors: S. Gupta, B. Schade, S. Kumar, C. Böttcher, R. Haag, S.K. Sharma
Affilation: University of Delhi, India
Pages: 308 - 311
Keywords: dendronized polymers, multiamphiphiles, non-ionic surfactants, Novozym-435, polyglycerol, polyethylene glycol
Several supramolecular architectures on the nanoscale have become important candidates for potential applications in nanomedicine, particularly for drug, dye, and gene delivery. Out of various conceptual extensions for the development of such molecular objects, our approach uses polymers as multi-functional, polydisperse cores to which dendrons are connected via pendant functional groups at every repeating unit and are termed as ‘dendronized polymers’ or ‘denpols’. These new class of non-ionic dendronized multiamphiphilic polymers have been prepared from biodegradable (AB)n-type diblock polymer synthesized from 2-azido-1,3-propanediol and polyethylene glycol (PEG)-600 diethylester using Novozym-435 as biocatalyst. The polymers were further functionalized with dendritic polyglycerols (G1 and G2) and octadecyl chains in different functionalization levels via click chemistry to generate dendronized multiamphiphilic polymers. All of the multiamphiphilic polymers spontaneously self-assemble in aqueous solution. Cryogenic transmission electron microscopy (cryo-TEM) further proved the formation of multiamphiphiles towards monodisperse spherical micelles of about 7-9 nm in diameter. The evidence from UV-vis and fluorescence spectroscopy suggest the effective solubilization of hydrophobic guests within the hydrophobic core of the micelles. These results demonstrate the potential of these dendronized multiamphiphilic polymers for the development of prospective drug delivery systems for the solubilization of poorly water soluble drugs.