Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 3: Materials for Drug & Gene Delivery

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Authors:A. Rajca, Q. Li, A. Date, C. Destache
Affilation:Creighton University School of Pharmacy & Health Professions, US
Pages:293 - 296
Keywords:NRTI conjugate, thermosensitive gel, HIV prophylaxis
Abstract:A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We have then taken this conjugated product and fabricated NRTI nanoparticles (NPs) as a sustained-release system. Furthermore, we have incorporated the NRTI-conjugated NPs into a thermosensitive gel to deliver the NPs vaginally as a prevention modality. Preliminary data is presented in the abstract.
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