Materials for Drug & Gene Delivery

Peptide-Mediated Cellular Delivery of Semiconductor Quantum Dots

Gemmill K., Delehanty J., Stewart M., Susumu K., Oh E., Deschamps J., Blanco-Canosa J., Dawson P., Huston A., Medintz I., US Naval Research Laboratory, US

Semiconductor CdSe/Zn quantum dots are ideal materials for biological imaging due to their superior optical properties over fluorescent proteins and organic dyes. However, cytosolic cellular delivery of quantum dots has been hindered by endosomal sequestration [...]

Exploiting the “protein corona effect” for targeted drug and gene delivery

Caracciolo G., Pozzi D., Capriotti A.L., Cavaliere C., Cardarelli F., Salomone F., Laganà A., Sapienza University of Rome, IT

When administered in vivo lipid nanoparticles (NPs) are immediately covered by a rich protein layer, known as “protein corona” that changes the size, aggregation state, and interfacial properties of the NP, giving it a biological [...]

Magnetic Field-Induced Cyclizations of Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles

Knipp R.J., Uradu O., Nantz M.H., University of Louisville, US

We studied a panel of thermally sensitive amino-esters and amino-carbonates to evaluate their cyclization rates on heating. After analyzing the influence of chain length, steric factors, gem-dimethylation and additional functionalities, we have determined which ester [...]

NanoBandage for Controlled Release of Topical Therapeutics

Patchan M., Calderon-Colon X., Benkoski J., Theodore M., Le H., Fuller B., Boggs N., Nelson A., Garza L., Sarkar K., Brandacher G., Patrone J., The Johns Hopkins University Applied Physics Laboratory, US

Burn injuries, trauma, and surgical procedures result in complex wounds, which can lead to pain, infection, and scarring. Management of complex wounds remains a critical challenge for the medical community and effective, localized treatments are [...]

Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment

Tsai M-H, Ling D., Shieh M.J., National Taiwan University, TW

Cancer is always the leading cause of deaths in worldwide. The aim of this research is to develop a new generation of chemotherapeutic drugs with both photothermal activated drug release and MRI diagnostic function. Carbon [...]

Study on the polymeric nanosphere with imaging functionality

Lin M-H, Liu T.Y., Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112 Taiwan (ROC), TW

The aim of this research was to develop a novel contrast agent with magnetic resonance (MR) imaging, fluorescent imaging and drug encapsulation functionalities. The zinc oxide (ZnO) nanoparticles and superparamagnetic iron oxide (Fe3O4) nanoparticleswas prepared [...]

Study of protoporphyrin IX-loaded silica hollow spheres for Photodynamic therapy

Tseng G-H, Liu T.Y., National Yang-Ming University of Taiwan, TW

In this study, PpIX was loaded in the shell of silica hollow sphere with the expectation that PpIX-loaded silica hollow spheres (PpIX-SHS) might be employed as a PDT agent with ultrasound image contrast. The PpIX-loaded [...]

Gold-Coated Liposomes Encapsulating Signaling Molecules for Initiating Cellular Communication

Orsinger G.V., Romanowski M., University of Arizona, US

To better understand the complex communication pathways of the tumor microenvironment, and therefore better design and develop therapies and diagnostics for cancers, experimental methods of probing cellular communication at a single to multi-cell level are [...]

Effect of cholesterol on the transfection efficiency of DOTAP-containing lipoplexes

Pozzi D., Cardarelli F., Salomone F., Marchini C., Amenitsch H., Caracciolo G., Sapienza University of Rome, IT

Here, we have studied the effect of cholesterol on the transfection efficiency (TE) of cationic liposomes made of 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) and dioleoylphosphocholine (DOPC) in Chinese hamster ovary (CHO) cells. We held the charge of the [...]

Reverse Thermoresponsive Polymers for Sustained Delivery of Therapeutic Agents

Mayadunne R., Balachandra A., Gunatillake T., Lindall C., CSIRO, AU

CSIRO has developed thermoresponsive polymers for encapsulation and sustianed release of bioactives. They are stable aqueous solutions over 24 months, easily pass through a 25 gauge needle at room temperature and immediately gel into a [...]

A Molecular Modeling Approach towards Engineering of Polymer Nanogels for Controlled Drug Delivery

Dutta R.C., Rai B., Tata Research Development and Design Centre, IN

Traditionally, a drug is administered initially at a higher dosage so as to repeat the next dose after several hours or days. This, besides being un-economical, results in side effects. Recently, there has been an [...]

Approaches to surface-functionalised materials for biomedical applications

Pitt D.W., Treharne A., Grossel M.C., University of Southampton, UK

There are many types of retinal disease which vary widely, with some being easier to treat than others. One such example is Age-Related Macular Degeneration (AMD) which is the largest cause of blindness for those [...]

Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin

Saravanakumar G., Shin J.M., Um W., Park J.H., Sungkyunkwan University, KR

Disulfide-containing HA dodecyl conjugates (HA-SS-DDTs) were synthesized using the facile thiol-exchange reaction as the carrier for intracellular delivery of doxorubicin (DOX). Owing to its amphiphilicity, HA-SS-DDT could form self-assembled nanoparticles in an aqueous condition. The [...]

Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis

Rajca A., Li Q., Date A., Destache C., Creighton University School of Pharmacy & Health Professions, US

A critical component to the prevention of the sexual transmission of HIV is adherence to the prevention modality. We have conjugated nucleoside-reverse transcriptase inhibitors (NRTIs) to a biocompatible polymer, PLGA using an amide bond. We [...]

Lipid nanoparticles for enhancing immune responses to protein antigens

Courant T., Reynaud H.L., Hoang A., Villiers C., Mittler F., Texier I., Marche P.N., Navarro F.P., CEA/LETI/MINATEC, FR

In the near future, novel vaccines will be needed, particularly nanoparticles-based vaccine formulations for figthing problematic infectious diseases like tuberculosis, AIDS/ HIV or malaria and also cancers. Here, we described the development of versatile chemical [...]

Nanosystem for targeting Treg in vivo

Bottini M., Bottini N., Sacchetti C., Rapini N., Rosato N., Magrini A., Bottini M., Bottini N., Sanford Burnham Medical Research Institute, US

Due to their ability to suppress the activity of autoreactive cells, “natural” CD4+ CD25high FoxP3+ T cells (Treg) are important drug targets for autoimmune diseases and malignancies. Immunological studies are revealing a growing subset of [...]

Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo

Chien M.-P., Gianneschi N.C., University of California San Diego, US

It has been shown that the morphology of nanomaterials greatly impacts the pharmacokinetic profile of the material, with larger micronscale fibril-like objects having longer circulation times while smaller nanomaterials show a greater rate of internalization [...]

Non-ionic Dendronized Multiamphiphilic Polymers as Nanocarriers for Biomedical Applications

Gupta S., Schade B., Kumar S., Böttcher C., Haag R., Sharma S.K., University of Delhi, IN

Several supramolecular architectures on the nanoscale have become important candidates for potential applications in nanomedicine, particularly for drug, dye, and gene delivery. Out of various conceptual extensions for the development of such molecular objects, our [...]

Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles

Render D., Rangari V., Samuel T., Ramapuram J., Pawar K., Jeelani S., Tuskegee University, US

The CaCO3 nanoparticles were derived from egg shells using sonochemical and mechanochemical methods. The glycerol and acetic acid were used as solvents in this process to avoid other toxic solvents. These nanoparticles were loaded with [...]

Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery

Sharifabad M.E., Mercer T., Sen T., University of Central Lancashire, UK

Superparamagnetic iron oxide nanoparticles (SPIONs) have become increasingly attractive materials in the field of Nano / Nano-biotechnology due to their potential applications in heteogeneious catalysis [1, 2], nanomedicine such as drug delivery [3, 4], cell [...]

Commercializing unique nanoparticle-imaging-delivery platform technology for enhanced cancer therapy

Fu A., NVIGEN, Inc., US

In this presentation, we will talk about a unique nanoparticle-imaging-delivery platform developed at NVIGEN, Inc. for enhanced cancer therapeutic applications. Our proprietary nanoparticle-imaging-delivery (NID™) technology is a hybrid platform comprised of an intrinsically signal-generating component [...]