Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)

Bio Nano Materials Chapter 2

Biomimetic Biphasic Nanocomposite Scaffold for Osteochondral Regeneration

Authors: N.J. Castro, C. O’Brien, L.G. Zhang

Affilation: The George Washington University, United States

Pages: 183 - 186

Keywords: growth factors, nanospheres, scaffold, osteochondral, interface

Abstract:
The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within the respective layer of our biphasic model. Human bone marrow derived mesenchymal stem cells were seeded, cultured, and evaluated. Two-week differentiation results illustrated increased collagen and calcium deposition on nanosphere containing scaffolds when compared to other test samples.


ISBN: 978-1-4822-0586-2
Pages: 806
Hardcopy: $209.95