Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 2: Bio Nano Materials

Biomimetic Biphasic Nanocomposite Scaffold for Osteochondral Regeneration

Authors:N.J. Castro, C. O’Brien, L.G. Zhang
Affilation:The George Washington University, US
Pages:183 - 186
Keywords:growth factors, nanospheres, scaffold, osteochondral, interface
Abstract:The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within the respective layer of our biphasic model. Human bone marrow derived mesenchymal stem cells were seeded, cultured, and evaluated. Two-week differentiation results illustrated increased collagen and calcium deposition on nanosphere containing scaffolds when compared to other test samples.
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