Zhang Y.J., Zhou W., Wen L.P.
University of Science and Technology of China, CN
Keywords: biomedical applications, cell interaction, peptides, phage display, rare earth nanomaterials
The induction of autophagy on exposure of cells to a variety of nanoparticles represents both a safety concern and an application niche for engineered nanomaterials. Using phage display, we have discovered an 11-amino acid peptide that binds to rare earth nanomaterials with high affinity and forms a stable coating layer on the surface of the nanocrystals. The peptide efficiently reduces sedimentation of the nanocrystals and the interaction of nanocrystals with cells and surfaces, while the addition of a homing peptide enhances the interaction of nanocrystals with the target cells and organs. In this presentation I will present the latest development on utilizing this novel peptide to enable biomedical applications for rare earth nanomaterials and formation of rare earth-based composite nanomaterials.
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Published: May 12, 2013
Pages: 210 - 212
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topic: Biomaterials
ISBN: 978-1-4822-0586-2