Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 2: Bio Nano Materials

Quatsomes: vesicles formed by self-assembly of sterols and

Authors:L. Ferrer-Tasies, E. Moreno-Calvo, M. Cano-Sarabia, M. Aguilella-Arzo, A. Angelova, S. Lesieur, S. Ricart, J. Faraudo, N. Ventosa, J. Veciana
Affilation:CSIC, ES
Pages:191 - 193
Keywords:nanovesicle, self-assembling, cationic surfactant, sterol, colesterol
Abstract:Thermodynamically stable nanovesicular structures are of high interest for academia and industry in a wide variety of application fields, ranging from nanomaterials preparation to nanomedicine. Here we show the ability of quaternary ammonium surfactants and sterols to self-assemble forming stable amphiphilic bimolecular building-blocks with the appropriate structural characteristics to form, in aqueous phases, closed bilayers, named quatsomes, with outstanding stability with time and temperature. Molecular self-assembling of cholesterol (Chol) and surfactant cetyltrimethylammonium bromide (CTAB) was studied by quasi-elastic light scattering (QELS), cryogenic transmission electron microscopy (cryo-TEM), turbidity (optical density) measurements and molecular dynamic simulations (MD) with atomistic detail, upon varying the cholesterol-to-surfactant molar ratio. As pure species, CTAB forms micelles and insoluble cholesterol forms crystals in water. However, our molecular dynamic simulations reveal that the synergy between CTAB and cholesterol molecules makes them self-assemble into bimolecular amphiphiles and then into bilayers in the presence of water. These bilayers have the same structure of those formed by double tailed unimolecular amphiphiles. Quatsomes have already shown to be effective nanostructures to enhance specific bioactivity of proteins and to protect them against premature degradation in topical pharmaceutical formulations.
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