Nano Science and Technology Institute
Nanotech 2013 Vol. 3
Nanotech 2013 Vol. 3
Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 1: Biosensing, Diagnostics & Imaging

Synthesis and Characterization of Functionalized Magnetic Nanoparticles for Biomedical Applications

Authors:L.F. Wang, Y.L. Lo, J.H. Ke
Affilation:Kaohsiung Medical University, TW
Pages:9 - 12
Keywords:magnetic nanoparticles, MRI contrast agents, drug delivery systems
Abstract:One-pot synthesized polyacrylic acid-modified iron oxide (PAAIO) was decorated with a polymer, which was served as a reservoir for a therapeutic agent or a fluorescent dye via chemical or physical approaches. PAAIO possess specific magnetic properties upon an exposed magnetic field, which endow them an attractive platform as a contrast agent for magnetic resonance imaging (MRI) and as a carrier for drug delivery systems. In this study, we are going to show some examples using surface-modified PAAIO in biomedical applications such as magnetofection,1 dual-modality nanoprobe, and theragnostics as a scheme shown below. Magnetofection is defined as the delivery of DNA,2 siRNA,3 or nucleic acids associated with magnetic nanoparticles to cells in the application of a magnetic field
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