Authors: A.M. Atta, H.A. Allohedan, A. Ezat, Z.A. Issa
Affilation: King Saud Unversity, Saudi Arabia
Pages: 442 - 445
Keywords: silver nanoparticle, core-shell, aggregates, characterization
The bioavailability of ingested silver nanoparticles (AgNPs) depends in large part on initial particle size, shape and surface coating, properties which will influence aggregation, solubility and chemical composition during transit of the gastrointestinal tract. In this respect, different types of citrate‐stabilized AgNPs coated with poly(vinyl-pyrrolidone) (PVP). Modified thiol derivatives of polyethylene glycol, polyacrylamides were exposed to synthetic human stomach fluid (SSF) (pH 1.5) and changes in size, shape, zeta potential, hydrodynamic diameter and chemical composition were determined during a 1 hr exposure period using Surface Plasmon Resonance (SPR), High Resolution Transmission Electron Microscopy/ Energy Dispersive X‐ray Spectroscopy (TEM/EDS), Dynamic Light Scattering (DLS) and X‐ray Powder Diffraction (XRD) combined with Rietveld analysis. Exposure of AgNPs to SSF produced stabilized SPR peak at 414 nm which changed according to the exposure time and the conditions of preparation of AgNPs. Changes in zeta potential, aggregation and morphology of the particles were also observed as well as production of silver chloride which appeared physically associated with particle aggregates.