Nano Science and Technology Institute
Nanotech 2013 Vol. 2
Nanotech 2013 Vol. 2
Nanotechnology 2013: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational (Volume 2)
Chapter 5: Micro & Nano Fluidics

Studies on Photothermal Effect in Nanofluidic Channel Toward Ultrasensitive Detection of Nonfluorescent Molecules Using Differential Interference Contrast Thermal Lens Microscope

Authors:H. Shimizu, K. Mawatari, T. Kitamori
Affilation:The University of Tokyo, JP
Pages:358 - 361
Keywords:nanofluidics, photothermal spectroscopy
Abstract:Absorption spectroscopy in nanofluidic channel was investigated for ultrasensitive detection of nonfluorescent molecules in nanospace. Recently, chemical analysis systems have been rapidly miniaturized from microspace to nanospace, which requires ultrasensitive detection of a broad range of molecules. Therefore, we have previously developed differential interference contrast thermal lens microscope (DIC-TLM) utilizing absorption and thermal relaxation (photothermal effect) for nonfluorescent molecules. Furthermore, the detection limit of the DIC-TLM was verified to be ~100 molecules level. However, heat transfer between the sample and nanochannel has remained as a problem to optimize its sensitivity. In this paper, photothermal effect in nanochannel has been studied using computational and experimental method. This paper will greatly contribute to creation of novel nanofluidic devices because the DIC-TLM is the first candidate to measure absorbance in nanospace.
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