Authors: C.J. Ferris, K.J. Gilmore, S. Beirne, D. McCallum, G.G. Wallace, M. in het Panhuis
Affilation: ARC Centre of Excellence for Electromaterials Science (ACES), Australia
Pages: 261 - 264
Keywords: cell, inkjet, biomaterials, bio-ink
This abstract summarises our recent work on the development of a bio-ink tailored for the controlled deposition of cells by inkjet printing. Direct printing of living cells is an emerging approach to the fabrication of tissue- or organ-like structures for application in regenerative medicine and in vitro drug screening and toxicology. Significant advances in bio-ink design are needed to continue the progression of this technology towards a clinically relevant biofabrication tool. Particularly, bio-inks for inkjet printing must simultaneously satisfy often disparate engineering and biological requirements, such as preventing cell settling and aggregation whilst retaining printability, without cytotoxic effects. The bio-ink described in this work uses a novel microgel suspension and biocompatible surfactants to achieve the above requirements to enable robust cell deposition from many-nozzle piezoelectric inkjet print heads. We employed this capability to fabricate a range of cell constructs and microarrays. We believe that the bio-ink described in this work is an important advance in inkjet cell printing.