Authors: R. Gerwig, P. Cesare, U. Kraushaar, S. Reinartz, M. Giugliano, A. Kilias, P. Ruther, A. Stett, M. Stelzle
Affilation: Natural and Medical Sciences Institute, NMI, Germany
Pages: 300 - 303
Keywords: CNT, PEDOT, neurotechnology, recording, stimulation, microelectrode array
The aim of this work was to design an advanced microelectrode material for neurotechnology. In order to improve signal-to-noise ratio, stimulation and sensing properties as well as cell viability, microelectrodes were modified with poly(3,4-ethylenedioxythiophene) (PEDOT) and carbon nanotubes (CNT). Coated electrodes show extraordinarily low impedance (< 20 kΩ for d = 30 µm) and significantly higher capacitance (4-10 mF/cm2) when compared to state-of-the-art neuro microelectrodes. Electron microscopy reveals the rough nanostructure of the composite material. Coatings can be produced in a reproducible quality and withstand intensive rinsing with solvents, autoclaving, UV irradiation, and repeated use in cell culture without delamination. The robustness and reproducibility make them feasible for real world applications. The applicability in neuronal reserach was shown in diverse in vitro as well as in vivo experiments. In summary, results demonstrate exceptional performance of nanostructured PEDOT-CNT microelectrodes. Based on these results we anticipate significant improvements in applications in in vitro neurotechnology as well as in neuroprostheses to become possible in the future.