Nano Science and Technology Institute
Nanotech 2013 Vol. 1
Nanotech 2013 Vol. 1
Nanotechnology 2013: Advanced Materials, CNTs, Particles, Films and Composites (Volume 1)
Chapter 2: Graphene

Nano Graphene Oxide as Drug Carrier for Antihypertensive Agent: Benazepril, Captopril and Losartan

Authors:J. Wang, Y. Long, C. Tao, H. Liu, H. Zhu, X. Zhou
Affilation:National University of Defense Technology, CN
Pages:239 - 242
Keywords:graphene oxide, drug carrier, ph-sensitive, controlled release
Abstract:Graphene oxide (GO) offers large surface and novel biocompatible properties that are currently being explored for advanced drug carriers. GO has a one-atom-thick two dimensional carbon system, which contains several kinds of oxygen functional groups on its basal planes and edges. Benefit from its great surface area, well-dispersion, novel biocompatible and lots of π-π stacking and H-bonding site, GO become a promising nano material as a drug carrier substance. Here we report nano GO as drug carriers and investigate its drug loading and release properties for Benazepril, Captopril and Losartan, which are used for antihypertensive treatment with short action time and poor water solubility. The loading capacity depends on the initial ratio of drug/GO ratio. The max loading of these three drugs are 1.12 mg/mg (Benazepril), 0.49 mg/mg (Captopril) and 0.30 mg/mg (Losartan) respectively.The release behaviors of these three drugs are pH-depended. The total amount of drug released in acidic environment is high than any other pH value. The pH-depended release property is due to the partial dissociation of hydrogen-bonding interaction under different pH conditions. The pH-dependent release property makes it possible to release drugs at determined target organs with different pH such as stomach and intestines.
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