Authors: M. Grodzik, E. Sawosz, M. Wierzbicki, A. Hotowy, M. Prasek, S. Jaworski, A. Chwalibog
Affilation: Warsaw University of Life Sciences, Poland
Pages: 218 - 221
Keywords: diamond nanoparticle, glioma, brain cancer, angiogenesis
Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and diamond nanoparticles) have antiangiogenic potential. However, their mechanism of action is unclear. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence signal transduction between cells. Our research shows, that diamond nanoparticles has affinity to VEGF-A protein.