Nano Science and Technology Institute
Nanotech 2012 Vol. 3
Nanotech 2012 Vol. 3
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 4: Cancer Nanotechnology & Nano Medical Sciences

VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor.

Authors:M. Grodzik, E. Sawosz, M. Wierzbicki, A. Hotowy, M. Prasek, S. Jaworski, A. Chwalibog
Affilation:Warsaw University of Life Sciences, PL
Pages:218 - 221
Keywords:diamond nanoparticle, glioma, brain cancer, angiogenesis
Abstract:Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and diamond nanoparticles) have antiangiogenic potential. However, their mechanism of action is unclear. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence signal transduction between cells. Our research shows, that diamond nanoparticles has affinity to VEGF-A protein.
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