Nano Science and Technology Institute
Nanotech 2012 Vol. 3
Nanotech 2012 Vol. 3
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 3: Materials for Drug & Gene Delivery

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Authors:N. Fomina, C. McFearin, M. Sermsakdi, J. Morachis, A. Almutairi
Affilation:University of California at San Diego, US
Pages:170 - 173
Keywords:NIR light degradable, NIR light responsive, self-immolative, chemical amplification, polymer, dendrimer, two-photon
Abstract:We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. Thus, it may be used for targeted delivery of therapeutics and/or imaging agents in vivo. It has been generally difficult to apply NIR light in vivo due to the limited number of photons that can reach a material to initiate a measurable response. We designed amplified response systems – polymers and dendrimers – to overcome this limitation. Their design is based on self-immolative molecular units that undergo a cascade of rearrangements leading to cleavage of multiple bonds and unraveling of the entire material in response to NIR light.
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