Nanotech 2012 Vol. 3
Nanotech 2012 Vol. 3
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)

Materials for Drug & Gene Delivery Chapter 3

Designing Responsive Materials with Chemically Amplified Sensitivity to NIR light

Authors: N. Fomina, C. McFearin, M. Sermsakdi, J. Morachis, A. Almutairi

Affilation: University of California at San Diego, United States

Pages: 170 - 173

Keywords: NIR light degradable, NIR light responsive, self-immolative, chemical amplification, polymer, dendrimer, two-photon

Abstract:
We employ near infrared (NIR) light as an external trigger for controlled material degradation and targeted release of a payload. NIR light can penetrate through tissues to an appreciable depth without scattering or damaging it. Thus, it may be used for targeted delivery of therapeutics and/or imaging agents in vivo. It has been generally difficult to apply NIR light in vivo due to the limited number of photons that can reach a material to initiate a measurable response. We designed amplified response systems – polymers and dendrimers – to overcome this limitation. Their design is based on self-immolative molecular units that undergo a cascade of rearrangements leading to cleavage of multiple bonds and unraveling of the entire material in response to NIR light.


ISBN: 978-1-4665-6276-9
Pages: 818
Hardcopy: $209.95