Nano Science and Technology Institute
Nanotech 2012 Vol. 3
Nanotech 2012 Vol. 3
Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy (Volume 3)
Chapter 3: Materials for Drug & Gene Delivery

Nanostructured cellulose materials: adsorption of antibiotics onto cellulose fibers functionalized with glycidylmethacrylate for the manufacturing of antibacterial fabrics

Authors:E. Vismara, G. Torri, A. Valerio, G. Graziani, A. Montanelli, L. Melone
Affilation:Politecnico di Milano, IT
Pages:174 - 177
Keywords:cellulose glycidylmethacrylate infections antibiotics
Abstract:Abstract: In this work we report how cotton fibers can be easily functionalized with glycidylmethacrylate (GMA) by means of the Fenton’s reaction and used for the manufacturing of biomedical textiles having significant capability to adsorb amoxicillin and vancomycin, two different antibiotics largely used in the clinical activity. The reversible adsorption capacity can be modulated by simple chemical treatments after the grafting of GMA on the cellulose backbone, through the epoxy ring opening by addition of water molecules or primary diamines having different aliphatic chain length (2 to 6 C atoms). The pristine cellulose fibers have no any adsorption capability. Such materials can find suitable application as wounds dressing or more in general for the topical administration of drugs.
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