Authors: A. Kopwitthaya, T.Y. Ohulchanskyy, M. Jeon, W-C. Law, Q. Xie, R.R. Chada, X. Xue, E.P. Furlani, C. Kim, P.N. Prasad
Affilation: University at Buffalo (SUNY), United States
Pages: 32 - 35
Keywords: magneto-plasmonic nanoplatform, photothermal cancer therapy, plasmonic enhanced bubble nucleation, LSPR-induced absorption, photoacoustic tomography
Multifunctional nanoplatforms are finding increasing use in a host of emerging applications in the fields of biophotonics and nanomedicine where they are used to target, probe, image and treat tissue at the cellular and subcellular level. In this presentation, we introduce a novel magneto-plasmonic nanoplatform that consists of a gold nanorod (GNR) and multiple Fe3O4 nanoparticles enclosed in a polymeric micelle-like structure as shown in Fig. 1. The combined magnetic and plasmonic functionality of the nanoplatform enables field-directed targeting and enhanced multimodal imaging and therapy of diseased tissue. The nanoplatform exhibits an intense NIR (λ=780 nm) absorption due to a longitudinal localized surface plasmon resonance (LSPR) of the GNR. This enables more efficient photonic stimulation and imaging in deep tissue due to an existence of the “transmission window” for biological tissues in the range of ~650-900 nm . We have demonstrated magnetophoretic control of the nanoformulations in vitro wherein an external field was used to accelerate uptake and aggregate the nanoplatforms in cancer cells. Following uptake, the nanoplatforms were illuminated with the femtosecond pulsed IR laser, which caused photothermal destruction of the cells due to plasmonically-enhanced heating and bubble generation (Fig. 1b and c).