Authors: S.A. Khashan, E.P. Furlani
Affilation: University at Buffalo SUNY, United States
Pages: 408 - 411
Keywords: magnetic particle-based transport, magnetophoretic transport, magnetophoretic microsystem, magnetic transport, bioseparation, high gradient magnetic separation
Applications of magnetic particles have grown dramatically in recent years, especially for emerging microfluidic applications in the fields of microbiology, nanomedicine and biotechnology where they are commonly used to sort and separate biomaterials. Magnetic particles are well suited for such applications because they can be functionalized to selectively bind to target biomaterials such as proteins, enzymes, nucleic acids or whole cells, thereby enabling control of these materials in microfluidic channels using an external field. To date, the analysis of magnetic field-induced particle transport has usually been limited to one-way particle-fluid coupling in which the flow field is uncoupled from particle motion. i.e. there is no momentum transfer from the particles to the fluid. In this presentation, a fully coupled analysis is presented. The analysis takes into account the impact of particle motion of the flow field and is used to study the transport and capture of magnetic particles in a microfluidic channel. Particle motion is predicted using a computational fluid dynamic CFD-based Lagrangian-Eulerian approach that takes into account dominant particle forces. The analysis demonstrates when two-way coupling is considered it reveals a cooperative effect between the magnetic force and a particle-induced fluidic force that enhances capture efficiency.