Nano Science and Technology Institute
Nanotech 2012 Vol. 2
Nanotech 2012 Vol. 2
Nanotechnology 2012: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational (Volume 2)
 
Chapter 4: Inkjet Design, Materials & Fabrication
 

Multi-functional silica microdot arrays by inkjet printing for biosensor applications

Authors:O. De Los Cobos, M. Lejeune, F. Rossignol, C. Carrion, C. Boissière, F. Ribot, C. Sanchez, X. Cattoën, M. Wong Chi Man, J.-O. Durand
Affilation:SPCTS, FR
Pages:255 - 258
Keywords:inkjet printing, mesoporous silica, click chemistry, biosensor
Abstract:Silica-based microarrays for molecular recognition are realized using a piezoelectric drop-on-demand inkjet printer. A sol containing tetraethyl orthosilicate (TEOS) and (3-azidopropyl)triethoxysilane is used as ink to print azido-functionalized mesoporous silica microdots arrays clickable with various alkyno-peptides, in accordance with the Huisgen 1,3 dipolar cycloaddition commonly called “click reaction”. In a similar route, a second ink is formulated integrating an alkyne silylated precursor. By using a multi-printhead system, a bi-material of intercrossed azido and alkyno-functionalized network can be built. The successive reactions with clickable peptides lead to the array multi-functionalization. Thereafter, peptides interactions with target biomolecules enable to perform multi-detection analyses. The success of the click chemistry, EISA and inkjet printing combination highly depends on the ink formulation, which is adjusted in regards to the viscosity and surface tension in the appropriate range for inkjet printing. Moreover, the aging time is carefully studied by 29Si NMR and DLS. Besides, the ink interactions at the printhead nozzle are investigated in terms of hydrophobicity and wettability. The use of an inox and a gold coated printheads are compared. Both require the addition of a hydrophobic agent to avoid the printhead wetting, however its rate can be reduced with the gold coated printhead.
ISBN:978-1-4665-6275-2
Pages:878
Hardcopy:$209.95
 
Order:Mail/Fax Form
Up
© 2014 Nano Science and Technology Institute. All Rights Reserved.
Terms of Use | Privacy Policy | Contact Us | Site Map