Nano Science and Technology Institute
Nanotech 2012 Vol. 1
Nanotech 2012 Vol. 1
Nanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites (Volume 1)
 
Chapter 4: Nanoparticle Synthesis & Applications
 

Nanogel Star Polymer Nanostructures of Controlled Size, Molecular Architecture and Functionality: No Assembly Required

Authors:R.D. Miller, J. Sly, V.Y. Lee, E. Appel, T. Nguyen, H. Nunes, M. Tjio, L. Gomez, M. McNeil, J. Munninghoff, A.E. Rowan
Affilation:IBM Almaden Research Center, US
Pages:464 - 467
Keywords:nanogel stars, synthesis, characterization, cargo loading, shell deposition, biomedical applications
Abstract:We have developed versatile routes to nanogel core, multiarm star polymeric unimolecular amphiphiles that provides exquisite control over molecular size, polydispersity, chain and periphery functionality which eliminate the dynamic equilibrium associated with polymeric micelles. . The number of arms is adjustable over the range from 20 to more than 100. The synthetic route is cheap and scalable and purification is simple providing an intrinsic advantage over dendrimers which are topologically similar. These materials readily encapsulate a variety of hydrophobic materials at reasonable loading levels (10-15%) without covalent binding. The cores and arms can be bio- stable, -degradable or –compatible. In addition to small molecules, nanoparticles including superparamagnetic materials can be encapsulated in the outer shell through ligand-mediated binding. The outer shell and periphery can also catalyze the controlled deposition of various inorganic shells including organosilicates and gold, the latter of which is formed by electrodeless deposition. The nanoparticles are multicompartmental and are useful as dual function reagents for therapeutics and imaging. The loaded particles spontaneously penetrate cells and can be tracked by fluorescence, MRI and PET. We will describe the preparation and characterization of these particles and nancomposites together with potential biomedical applications
ISBN:978-1-4665-6274-5
Pages:804
Hardcopy:$209.95
 
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