Nano Science and Technology Institute
Nanotech 2011 Vol. 3
Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 7: Environment, Health & Safety

Assessment of comparative toxicity of nano- and microparticles of magnetite

Authors:B.A. Katsnelson, L.I. Privalova, T.D. Degtyareva, S.V. Kuzmin, M.P. Sutunkova, I.A. Minigalieva, E.P. Kireyeva, M.Y. Khodos, V.Y. Shur, E.V. Nikolaeva, I.E. Valamina, L.G. Tulakina, S.V. Pichugova, J.B. Beykin
Affilation:Federal State Institution of Sciences Medical Research, RU
Pages:537 - 540
Keywords:nanoparticles, magnetite, toxicity
Abstract:Assessment of toxicity of 10 nm, 50 nm and 1 um Fe3O4 particles based on shift in the cell population of the broncho-alveolar lavage fluid after their intratracheal instillation into lungs of rats and on a set of indices of the organism’s status following repeated intaperitoneal injections showed that, in equal mass doses, nanoparticles were far more toxic than microparticles but induced a more active protective response of alveolar phagocytosis. The latter fact was established with optical, electronic, and SE atomic force microscopy.
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