Nano Science and Technology Institute
Nanotech 2011 Vol. 3
Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 6: Nano Medical Sciences & Neurology

Polymersome macromolecule delivery across intact human skin

Authors:C. Pegoraro, S. MacNeil, G. Battaglia
Affilation:University Of Sheffield, UK
Pages:428 - 431
Keywords:drug delivery, transdermal, polymersomes
Abstract:Skin is a highly stratified and impermeable tissue that confers specific size, charge, hydrophilic and lipophilic constraints on the types of molecules that can diffuse across it. Here we report the use of a novel drug delivery vehicle based on flexible and tough nano-sized polymeric vesicles (otherwise known as polymersomes) formed from high molecular weight, amphiphilic, pH-sensitive block copolymers. These polymersomes transport high molecular weight dextran efficiently across both a synthetic polycarbonate porous barrier and intact human skin without losing mechanical stability (as confirmed by Dynamic light Scattering, DLS). For polycarbonate membranes, the efficiency of dextran delivery via polymersomes was 60.0% compared to only 33.0% for free dextran. For human skin, delivery of dextran-loaded polymersomes was 27.0% compared to only 4.3% for free dextran. Confocal Laser Scanning Microscopy was used to confirm the diffusion of polymersomes across skin and the delivery of dextran.
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