 | Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 6: Nano Medical Sciences & Neurology |
Nanostructural Effects of Mitomycin C Applications on Scleral Collagen Fibrils: Atomic Force Microscopy Observation | |
| Authors: | S. Choi, Y. Cheong, E. Kwon, G.B. Jung, H.-J. Lee, J.-H. Shin, K.-H. Jin, H.-K. Park |
| Affilation: | Kyung Hee University, KR |
| Pages: | 475 - 477 |
| Keywords: | atomic force microscopy, human sclera, collagen fibrils, Mitomycin C, diameter and D-periodicity |
| Abstract: | This study was to investigate the effects of Mitomycin C on the scleral collagen surfaces by atomic force microscopy (AFM). Two non-contact mode AFM machines were used to observe changes in the morphological characteristics of human scleral surfaces before and after 0.02% Mitomycin C application for 1, 3 and 5 minutes. From AFM topography and deflection images of the collagen fibril, the morphological characteristics of scleral fibrils including the fibril diameter and D-banding were measured using line profile. The sclera collagen fibril treated with 0.02% Mitomycin C for 1 min showed no significant increase in mean fibril diameter (155.04 ± 17.46 nm) and the mean D-periodicity (70.02 ± 3.33 nm), compared to the control group. However, the scleral collagen fibrils treated with 0.02% Mitomycin C for 3 and 5 min showed a significant increase in mean fibril diameter (182.33 ± 16.33 nm and 199.20 ± 12.40 nm) and mean D-periodicity (70.27±13.66 nm and 72.75 ± 19.32 nm), compared to the control group. This study examined the structural changes in the scleral collagen fibrils before and after Mitomycin C application by AFM technique. The results indirectly suggest that long-term Mitomycin C application might increase the incidence of complications like a scleromalcia. |
| ISBN: | 978-1-4398-7138-6 |
| Pages: | 852 |
| Hardcopy: | $199.95 |
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