Nano Science and Technology Institute
Nanotech 2011 Vol. 3
Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 5: Cancer Nanotechnology

Enhanced Cell Electro-permeabilisation Combined with Phototherapy to Target-Killing Cancer Cells by Using Multi Functional Carbon Nanotubes

Authors:P-C Lee
Affilation:National Taiwan University, TW
Pages:379 - 381
Keywords:carbon nanotubes, electro-permeabilisation, photodynamic therapy, hyperthermia
Abstract:Carbon nanotubes (CNTs) have been proposed and actively explored as multifunctional innovative carriers for drug delivery. This project presents a new modality for cell electro-permeabilisation based on the use of CNTs and external static electric fields to achieve highly drug delivery efficiency. Besides, CNTs are unique materials that absorb infrared (IR) radiation in the specific spectral window where body tissues are most transparent. Absorbed IR promotes molecular oscillation leading to efficient heating of the surrounding environment. By using these characteristics of CNTs, we conjugated photosensitizers (PS) on chemically functionalized single-wall carbon nanotubes (f-SWNTs) to combine photodynamic therapy and hyperthermia for killing cancer cells specifically and effectively. Thus, CNT complex drug delivery is promising for improving the efficacy of drug delivery and treatment to decrease side effects for future cancer therapy.
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