Nano Science and Technology Institute
Nanotech 2011 Vol. 3
Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy
 
Chapter 3: Bio Nano Materials
 

siRNA and Paclitaxel Loaded PEG-PCL-PEI Tri-block Polymeric Micelle for Gene and Chemo-therapy Applications in Multidrug-resistance cancer cell

Authors:C.-Y. Hsu
Affilation:National Chung Hsing University, TW
Pages:225 - 228
Keywords:siRNA, paclitaxel, polymeric micelle, multidrug-resistance
Abstract:An annoying problem of chemotherapy was the drug resistance of cancer cell which was expression of multidrug-resistance associated proteins and resulted in ineffective treatment. To conquer this problem, a small interfering RNA (siRNA) molecule and paclitaxel (PTX) were used as gene and chemo-therapy drug to make drug resistance cancer cell sensitizing to chemotherapeutic drug. For achieving the mentioned objective, tri-block copolymer, polyethylene glycol-polycaprolactone-polyethylenimine (PEG-PCL-PEI) forming micelle was utilized to encapsulate the PTX in the core of micelle and to attract the siRNA on the corona of PEI in this study.
siRNA and Paclitaxel Loaded PEG-PCL-PEI Tri-block Polymeric Micelle for Gene and Chemo-therapy Applications in Multidrug-resistance cancer cellView PDF of paper
ISBN:978-1-4398-7138-6
Pages:852
Hardcopy:$199.95
 
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