Nanotech 2011 Vol. 3
Nanotech 2011 Vol. 3
Nanotechnology 2011: Bio Sensors, Instruments, Medical, Environment and Energy

Nanoparticles in Imaging Technologies Chapter 2

Indium Phosphide : Cadmium Free Quantum Dots for Cancer Imaging and Therapy

Authors: H. Chibli, L. Carlini, S. Park, N. Dimitrijevic, J.L. Nadeau

Affilation: McGill University, Canada

Pages: 133 - 136

Keywords: InP, reactive oxygen species, cancer imaging, toxicity

Abstract:
We synthesised Indium phosphide (InP) quantum dots (QDs) with different shell layer. We demonstrate highly fluorescent labeling of cell lines after nonspecific endocytosis of the QD. With spin-trap electron paramagnetic resonance (EPR) spectroscopy and reporter assays we determined the nature of reactive oxygen species generated. The sulforodhamine B (SRB) viability assay indicates very low cytotoxicity in all cell line tested. These data indicate that straightforward methods of synthesis and solubilization result in InP QDs that are a viable alternative to cadmium-containing particles for biological applications.

Indium Phosphide : Cadmium Free Quantum Dots for Cancer Imaging and Therapy

ISBN: 978-1-4398-7138-6
Pages: 852
Hardcopy: $199.95