Nano Science and Technology Institute
Nanotech 2011 Vol. 1
Nanotech 2011 Vol. 1
Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites
 
Chapter 3: Nanoparticle Synthesis & Applications
 

Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging

Authors:E.-K. Lim, S. Haam
Affilation:Yonsei University, KR
Pages:359 - 362
Keywords:nanoprobe, magnetic resonance imaging, multimode, fluorescent
Abstract:We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe2O4 nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent 1-pyrenebutyric acid through an esterification process, is capable of self-assemblyandmaintaining a highUVfluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent andmagnetic properties as well asmaintaining highwater-solubility. Consequently,weproved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models.
ISBN:978-1-4398-7142-3
Pages:882
Hardcopy:$199.95
 
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