Nanotech 2011 Vol. 1
Nanotech 2011 Vol. 1
Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites

Nanoparticle Synthesis & Applications Chapter 3

Rifampicin nanosuspension production using microfluidic device

Authors: J.N. Schianti, N.N.P. Cerize, A.M. Oliveira, S. Derenzo, M.R. Gongora-Rubio

Affilation: Polytechnic School - University of São Paulo, Brazil

Pages: 229 - 232

Keywords: Rifampicin, nanoparticles, nanoprecipitation, microfluidic

Abstract:
In this work the results of a study of Rifampicin nanoprecipitation through antisolvent technique are presented, using microfluidic devices. Rifampicin is commonly used in Tuberculosis treatment and presents variability in bioavailability. The particle size and morphology were evaluated by observing the influence of fluid flow rates, the relation between flow rates, the presence of surfactants and Rifampicin concentrations. The size and morphology contribute to accelerate the dissolution rates, increasing biovailability.


ISBN: 978-1-4398-7142-3
Pages: 882
Hardcopy: $199.95

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