Nano Science and Technology Institute
Nanotech 2011 Vol. 1
Nanotech 2011 Vol. 1
Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites
Chapter 3: Nanoparticle Synthesis & Applications

Rifampicin nanosuspension production using microfluidic device

Authors:J.N. Schianti, N.N.P. Cerize, A.M. Oliveira, S. Derenzo, M.R. Gongora-Rubio
Affilation:Polytechnic School - University of São Paulo, BR
Pages:229 - 232
Keywords:Rifampicin, nanoparticles, nanoprecipitation, microfluidic
Abstract:In this work the results of a study of Rifampicin nanoprecipitation through antisolvent technique are presented, using microfluidic devices. Rifampicin is commonly used in Tuberculosis treatment and presents variability in bioavailability. The particle size and morphology were evaluated by observing the influence of fluid flow rates, the relation between flow rates, the presence of surfactants and Rifampicin concentrations. The size and morphology contribute to accelerate the dissolution rates, increasing biovailability.
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