Authors: S. Abbasi, P. Arghya, K. Afshan, S. Prakash
Affilation: McGill University, Canada
Pages: 74 - 76
Keywords: nanoparticles, biodegradable, siRNA, breast cancer
Polyethylenimine (PEI)-coated human serum albumin (HSA) nanoparticles form suitable biocompatible carriers for therapeutic molecules. Small interfering RNA (siRNA) molecules have suggested great promise as a future therapy for breast cancer. In order to overcome the problems of degradation and low cellular transfection associated with siRNA, PEI-HSA nanoparticles are used. These nanoparticles are characterized to allow efficient delivery of siRNA to MCF-7 breast cancer cells.