Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 7: Nano Medical Sciences

Determination of the Electroporation Threshold for pulses from 95 ns to 20 us

Authors:G. Saulis, S. Balevicius, R. Saule, V. Stankevic, N. Zurauskiene
Affilation:Vytautas Magnus University, LT
Pages:506 - 509
Keywords:nanoporation, mouse hepatoma, electropermeabilization
Abstract:The dependences of the fraction of electroporated mouse hepatoma MH-22A cells on the pulse intensity were obtained for the cells exposed to single square-wave electric pulses with the durations from 95 ns to 20 us. The amplitude of an electric pulse was varied from 0.4 to 12 kV/cm. Increasing the intensity of the electric field pulse increased the fraction of electroporated cells. The electric field which leads to a given percentage of electroporation decreased with increasing the pulse length. The dependence of the amplitude of the electric pulse required to electroporate 50% of mouse hepatoma MH-22A cells on the pulse duration was also determined.
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