Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 7: Nano Medical Sciences

Multi-Modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications

Authors:A. Bumb, C.A.S. Regino, M. Bernardo, P.J. Dobson, P. Choyke, M.W. Brechbiel
Affilation:National Cancer Institute, US
Pages:428 - 431
Keywords:diagnostics, imaging, nanoparticle, lymph node, magnetic resonance, optical
Abstract:Accurate characterization of the first draining sentinel lymph nodes in primary tumors is a challenging task where current methods rely on nodal size as the primary yardstick for differentiating benign from malignant nodes. Other parameters such as the nodal shape, contour, and level of enhancement may also provide useful information. We have developed a dual reporting nanoparticle by encasing ultrasmall superparamagnetic iron oxide nanoparticles in a thin ~4nm layer of silica containing near infrared dye Cy5.5. Mice given intracutaneous injection of particle in the foot pad reveal visualization of the primary draining nodes and histology confirmed particle presence. Studies have been directed at diagnosing tumor formation where, the particle could first be used to characterize lymph node by MR, followed by fluorescence identification during surgery, and further histology using its fluorescence and iron. The particle has also been made tri-modal by conjugating radiolabeled-antibody to its surface for nuclear imaging. This silica-coated iron oxide nanoparticle (SCION) allows for verification of localization, characterization of nearby physiology, and quantification. During each stage of development, SCION was characterized for surface charge, structure, optical response, and magnetic properties. Cell viability, biodistribution, pharmacokinetics, MR, optical, and nuclear imaging studies have also been conducted.
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