Papers:
Qdot® nanocrystals in intracellular flow: ZAP-70, KI-67 and five-colors fluorophores panel
Sotnikov I., Jaron S., Konopleva M., O’Brien S., Andreeff M., Hildebrant J., Manis J., Brown J., Vorobjev I., Barteneva N., Immune Disease Institute, Harvard Medical School, US
We present, for the first time, the methodological approach for the measurement of cytoplasmic Zap-70 and nuclear Ki-67 proteins with Qdot® nanocrystals-labeled antibodies. Mononuclear cells from chronic lymphoid leukemia patients were used to detect Zap-70, [...]
Multi-Modal Superparamagnetic Nanoprobe: Harnessing Magnetic, Nuclear, and Optical Power for Diagnostic Imaging Applications
Bumb A., Regino C.A.S., Bernardo M., Dobson P.J., Choyke P., Brechbiel M.W., National Cancer Institute, US
Accurate characterization of the first draining sentinel lymph nodes in primary tumors is a challenging task where current methods rely on nodal size as the primary yardstick for differentiating benign from malignant nodes. Other parameters [...]
Plasmonic Nanobubbles: tunable and transient probes for cancer diagnosis, therapy and theranostics
We report a tunable theranostic probe that can support the diagnosis, therapy and therapy guidance in one process in individual cancer cells. This probe is a plasmonic nanobubble (PNB), which is not a particle but [...]
3D-RISM-KH approach for biomolecular modeling at nanoscale: Thermodynamics of fibril formation and beyond
Blinov N., Dorosh L., Wishart D., Kovalenko A., University of Alberta/National Institute for Nanotechnology, CA
As an alternative to the conventional solvation models, we propose to use the three-dimensional molecular theory of solvation (3D-RISM-KH approach) as an essential part of a multiscale approach for nanomedical applications. Based on the rigorous [...]
3D Molecular Theory of Solvation Coupled with MD for Nanomedical Sciences
We have coupled the statistical-mechanical, molecular theory of solvation (a.k.a. 3D-RISM-KH) with molecular dynamics (MD) simulation in the Amber molecular dynamics package to contract solvent degrees of freedom. This included a number of accelerating schemes [...]
Creation of Protein Nanoarrays using Dip-Pen Nanolithography
This presentation describes the creation of protein nanoarrays on a nitrocellulose surface using Dip-Pen Nanolithography and their use in studying protein:protein interactions in an assay format.
Nanoparticles that facilitate imaging of biological tissue and methods of forming the same
A superparamagnetic nanoparticle (SPIOM) containing antimyoglobin coated and polyethylene encapsulated biotin-avidin-iron-oxide core in center may be provided according to an example in the invention. These nanoparticles may be used as imaging contrast agents due to [...]
Imaging Molecules and cells
Proteins provide the building blocks for multicomponent molecular units, or pathways, from which higher cellular functions emerge. These units consist of either assemblies of physically interacting proteins or dispersed biochemical activities connected by rapidly diffusing [...]
Chromatographic Purification of Bacteriophages for Improved Surface Capture of Bacteria – Towards a General Approach
Naidoo R., Singh A., Glass N., Arya S., Evoy S., National Institute for Nanotechnology, University of Alberta, CA
We report in this study the largest surface capture density of E Coli using the wild-type T4 bacteriophage; whereby higher surface capture density can enable higher sensitivities for surface-based biosensors. This was possible due to [...]
Design of a lipid nanovesicle system encapsulating bacteriophages integrated in a multiple emulsion formulation: a proof-of-concept
Balcão V.M., Azevedo A.F., Castro L.M., Costa C.I., Santos S., Matos C.M., Moutinho C.G., Teixeira J.A., Azeredo J.C., University Fernando Pessoa and Institute for Biotechnology and Bioengineering, PT
of the optimized bacteriophage-encasing nanovesicles encompassed determination of particle hydrodynamic size, size distribution and particle charge via DLS, surface morphology via CRYO-SEM, and thermal analysis via DSC, whereas antimicrobial activity of the nanoemulsions produced was [...]
Bacteriophages and cryogels: A new efficient tool in Bioseparation
Noppe W., Galaev I.Y., Mattiasson B., Deckmyn H., Katholieke Universiteit Leuven Campus Kortrijk, BE
In the field of affinity chromatography, the search for new ligands is of great interest, where apart from the use of antibodies as affinity ligands, also synthetic ligands were introduced. Special attention was focused on [...]
The Method of Instant Amplification of the MCG&MEG Signals
Simultaneous amplification of the piking up MCG&MEG neurosignals by an on-site magnetic flow has been implemented. Matrix of the sensing micro-nanocoils are distributed under the heart or brain surface with temperature of the body. Magnetic [...]
Morphological Studies on Nano-Neuronal Interactions
Nanostructures are expected to play a key role in the fundamental investigation of neuronal activity at the nanoscale level. Neurons are complex structures with feature sizes ranging from the millimeter to micron to nanoscale regimes. [...]
Reliability in Nano-Engineering: Nuclear Spin of Magnesium-25 as Reliability Factor in Molecular and Biomolecular Nanoreactors
The trend of nanoscaling brings engineering down to the dimensions of molecular structures. However, it poses the problem of how to create a reliable system from molecular components which experience permanent thermal and environmental fluctuations. [...]
Nanoscale structure and property changes in collagen fibrils on the extracorporeal shockwave therapy applications of the rat Achilles tendon injury
Choi S., Lee G.J., Chon J., Chae S.-J., Yoo S.-D., Park H.K., Park J.H., Kim K.S., Park H.K., Park J.H., Kyung Hee University, KR
Extracorporeal shockwave therapy (ESWT) is popular in the treatment of musculo-skeletal injuries. However, the mechanism by which such therapy might have an effect on tendon injury is unknown. The Achilles tendons are mainly composed of [...]
Traceability of Polyethylcyanoacrylate nanoparticles through the Startum Corneum
We followed nanoparticles through the stratum corneum using tape stripping and the nanoparticles quatification was done using photoluminescence. We found some interesting data at 3 hrs of application of nanoparticles because it seems like nanoparticles [...]
Electrochemical Mechanics of Nanometer-Scaled Structural Layers of Bacterial Spores
The early events in the nutrient and non-nutrient germination of Bacillus subtilis spores are considered in combination with the properties of nanometer-scaled spore structural layers. All structural, not metabolically mediated, transformations at the early steps [...]
Bioluminescent quantum dots induced photodynamic therapy in vitro
Photodynamic therapy (PDT) is an innovative method for cancer treatment which involves the administration of a photosensitizing agent followed by exposure to the visible light. Appreciate light source to induce photosensitizing agent is the key [...]
Bimolecules in multimodal and multifunctional bioimaging database: potentials and applications
Oligonucleotides are biomarkers in gene expression imaging and proteins for imaging proteomics based on these end product molecules as visible by MRI and PET to give structural and metabolic information in diseased tissue. We compiled [...]
Preparation and Characterization of Coenzyme Q10-Loaded Nanostructured Lipid Carriers as Delivery Systems for Cosmetic Component
Nanostructured Lipid Carrier (NLC) was a kind of nanosized carrier for lipophilic active compounds. Coenzyme Q10 (CoQ10) which is a versatile anti-oxidant is practically insoluble and chemically labile in water and should be incorporated in [...]
Analysis of the Relationships Between the Parameters of the Electric Pulse
Theoretical relationships between the parameters of the electric pulse which is necessary for the poration of the cell have been obtained. Analysis has been made for the square wave, exponential and sine wave ac electric [...]
Determination of the Electroporation Threshold for pulses from 95 ns to 20 us
The dependences of the fraction of electroporated mouse hepatoma MH-22A cells on the pulse intensity were obtained for the cells exposed to single square-wave electric pulses with the durations from 95 ns to 20 us. [...]
Computational Modeling of Electromagnetically Induced Heating of Magnetic Nanoparticle Materials for Hyperthermic Cancer Treatment
We present results on the computational modeling of electromagnetically induced heating for the purpose of hyperthermic cancer treatment with magnetic nanoparticle fluids. Magnetic hyperthermia can therefore be used for direct targeting and destruction of tumors [...]
Leveraging Ontologies for Improved Medical Outcomes Assessment: Implementing Medical Management Technology to Drive Innovation
Sensor data - such as that produced by many kinds of nanotechnologies - can be difficult to manage and maintain. This is especially true in areas of biomedicine where contextual information is important to capture [...]
Polyethylene-oxide (PEO) linear nano-polymer directly stimulates endothelium and protects myocardium from focal ischemia-reperfusion injury via eNOS pathway in rats
Medical grade Nano-polymers (NP) used to enhance circulation, drug and gene delivery. Injection of Polyethylene-oxide (PEO) increase tissue perfusion and decrease mean blood pressure in animal models. Polyethylene-oxide (PEO) NP’s ultra high molecular weight (2-5 [...]
Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Industry sector: Medical & Biotech
Topics: Biomaterials, Cancer Nanotechnology
ISBN: 978-1-4398-3415-2