Authors: Y. Choi, H. Torikai, D.Y. Lee, Z. Li, D. Lo, G. Qin, C.H. Tung, E. Tasciotti, R. Raphael, S.L. Biswal, S. Ang, D.A. Lee, K.C. Li, L.J.N. Cooper
Affilation: M.D. Anderson Cancer Center, United States
Pages: 376 - 379
Keywords: electroporation, indium, gold nanoparticle, T cell
we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.