Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

	Nanotech 2010 Vol. 3 Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy Chapter 6: Cancer Nanotechnology
	Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells
Authors:	Y. Choi, H. Torikai, D.Y. Lee, Z. Li, D. Lo, G. Qin, C.H. Tung, E. Tasciotti, R. Raphael, S.L. Biswal, S. Ang, D.A. Lee, K.C. Li, L.J.N. Cooper
Affilation:	M.D. Anderson Cancer Center, US
Pages:	376 - 379
Keywords:	electroporation, indium, gold nanoparticle, T cell
Abstract:	we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.
ISBN:	978-1-4398-3415-2
Pages:	880
Hardcopy:	$189.95

Order:	Mail/Fax Form
Special:	3 CD Set — 15% off with Free Shipping
Up