Authors: V. Vergaro, Z. Zheng, X. Zheng, Y.M. Lvov, G. Giovinazzo, A. Santino, R. Cingolani, R. Rinaldi, S. Leporatti
Affilation: National Nanotechnology Laboratory (NNL) of CNR-INFM, Italy
Pages: 393 - 394
Keywords: nanocarriers, nanocolloids, nanotubes, oleosomes, cancer, nanotechnology
Drug nano-colloids encapsulated by combination of layer by layer (LbL) techniques and ultrasonication, phytochemical encapsulated-artificial oleosomes and drug-loading clay nanotubes have been uptaken by neoplastic cells. Morpho- mechanical changes induced by such nanocarriers in living cancer cells have been detected by a combination of high resolution optical and scanning force microscopy techniques.Elasticity, which is considered a relevant marker of vitality and neoplastic invasiveness of cancer cells, has been quantified by Force Mapping Mode.The Young’s modulus of living treated cells is significantly modified in a time- and drug- carrier concentration-dependent manner as a consequence of modifications in cytoskeletal and contractile filament organization observed by selective fluorescent stainings.