Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Chapter 5: Drug & Gene Delivery

Formation of Drug Nanoparticles from Microemulsions

Authors:S. Magdassi, K. Margulis-Goshen
Affilation:Hebrew University of Jerusalem, IL
Pages:308 - 311
Keywords:nanoparticles, microemulsions
Abstract:A new method for preparation of water-insoluble organic nanoparticles, in a form of re-dispersible powder will be described. The method is based on rapid conversion of nanodroplets into nanoparticles, by evaporation of all volatile solvents from an emulsions containing a dissolved drug. The nanodroplets are formed by spontaneous assembly in microemulsion systems, in which a drug is dissolved in an “oil” phase which is a volatile solvent. The new method does not require any special instrumentation such as high pressure homogenizers. The conversion of the nanodroplets into nanoparticles takes place during rapid evaporation by spray drying.Dispersing the powder in water yields almost transparent solutions, with a dramatic improvement in dissolution rate.
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