Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy

Drug & Gene Delivery Chapter 5

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

Authors: M.S. Yusuf, A.D. Miller, C.H. Prata

Affilation: Imperial College Gene Therapies Centre, United Kingdom

Pages: 364 - 367

Keywords: liposome, Mannose receptor, siRNA, macrophage

Abstract:
Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is to be developed into a novel disease modifying agent in the treatment of systemic autoimmune diseases such as rheumatoid arthritis

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

ISBN: 978-1-4398-3415-2
Pages: 880
Hardcopy: $189.95