Nano Science and Technology Institute
Nanotech 2010 Vol. 3
Nanotech 2010 Vol. 3
Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
 
Chapter 5: Drug & Gene Delivery
 

Novel nanostructured drug delivery technology to enhance bioavailability, increase solubility and drug loading

Authors:G. Heltovics, Zs. Ötvös, G. Filipcsei, F. Darvas
Affilation:NanGenex Inc., HU
Pages:338 - 341
Keywords:drug nanoparticles, increase solubility, enhanced bioavailability
Abstract:In the presentation we will discuss the perspectives and pharmacokinetic benefits of the nanosized active molecules over the parent active molecules. The bioavailability of reference and nanosized drug was determined after oral administration (30 mg/kg) in fasted state at Sprague-Dawley rats using international standard protocols. Nanosized drug had an AUC15-360 min value of 6412 µg∙min/ml while this value after reference treatment was 940.1 µg∙min/ml. The ratio of the two AUC values (AUC15-360 min (nanosized) / AUC15-360 min (reference)) was 6.82. Work was supported by the Hungarian Grant KMOP-1.1.1-09/1-2009-0025.
ISBN:978-1-4398-3415-2
Pages:880
Hardcopy:$189.95
 
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