Authors: F. Benyettou, I. Chebbi, Y. Lalatonne, O. Sainte-Catherine, M. Di Benedetto, M. Lecouvey, O. Seksek, L. Motte
Affilation: Université Paris 13, France
Pages: 258 - 261
Keywords: iron oxide nanoparticles , multimodal nanoplatform, HMBPs, cancer therapy, diagnosis
The goal of this project is to elaborate new multifunctional magnetic nanovectors to vectorize biological interest molecules for therapy and diagnostic applications. Indeed, iron oxide nanoparticles, tanks to their magnetic properties, are used as contrast agents for MRI. Moreover the specific surface coating by interest molecules permit to consider them as a drug delivery vehicle for therapeutic molecules. Liposomes are also considering as good candidates for drug delivery systems. Indeed, lipid vesicle encapsulation allows protection of the agent against enzymatic degradation, and reduces the dose and toxics effects. However, the selective and controlled release of the drug out of the vesicles is still difficult to master, especially at cell and tissue levels. This can be achieved by magnetic targeting. Recent studies have shown that in addition to inhibit bone resorption, Hydroxymethylene Bisphosphonates molecules present anti-tumour properties in variety of cancer. However, these properties can not be exploited due to their very high affinity to bone. In order to overcome this problem, we use two strategies. The first one is the vectorization trough iron oxide nanocrystal surface functionalization. The second one was to use superparamagnetic liposomes.